The effect of tranexamic acid on blood loss in orthognathic surgery: a meta-analysis of randomized controlled trials

被引：37

作者：

Song, Guodong ^{[1
]}

Yang, Ping ^{[2
]}

Hu, Jing ^{[1
]}

Zhu, Songsong ^{[1
]}

Li, Yunfeng ^{[1
]}

Wang, Qiushi ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Stomatol, Dept Oral & Maxillofacial Surg, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610041, Peoples R China

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2013年 / 115卷 / 05期

关键词：

LUMBAR SPINE SURGERY; TRANSFUSION REQUIREMENTS; CLINICAL-TRIAL; ORAL-SURGERY; QUALITY; EFFICACY;

D O I：

10.1016/j.oooo.2012.09.085

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The objective of this article was to evaluate the efficacy of tranexamic acid on blood loss in orthognathic surgery. A meta-analysis was performed. Study Design. The PubMed and EMBASE electronic databases were searched until June 30, 2012. Eligible studies were restricted to randomized controlled trials (RCTs). Results. Four RCTs with 183 patients were included. The results showed that intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). However, the postoperative levels of hemoglobin (Hb) and hematocrit (Hct) have no significant difference compared with placebo groups (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively). Conclusions. This meta-analysis confirms that tranexamic acid can effectively reduce intraoperative blood loss in orthognathic surgery, especially by intravenous administration. But, tranexamic acid cannot affect postoperative levels of Hb and Hct.

引用

页码：595 / 600

页数：6

共 37 条

[1]

Aguilera X, 2012, ACTA ORTHOP BELG, V78, P68

[2] The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial [J].

Alimian, Mahzad ;

Mohseni, Masood .

JOURNAL OF CLINICAL ANESTHESIA, 2011, 23 (08) :611-615

[3]

Anderson J A, 1986, Int J Adult Orthodon Orthognath Surg, V1, P133

[4]

Baliga M, 2006, Kathmandu Univ Med J (KUMJ), V4, P109

[5] Retrospective analysis of autologous blood use in bimaxillary repositioning osteotomy surgery: a quality improvement study [J].

Boettger, Sebastian ;

Streckbein, Philipp ;

Hartmann, Bernd ;

Schaaf, Heidrun ;

Howaldt, Hans Peter ;

Junger, Axel .

TRANSFUSION, 2009, 49 (08) :1747-1753

[6] Extensive Stroke Associated with Tranexamic Acid Therapy [J].

Cabrera-Naranjo, Fernando ;

Gonzalez-Hernandez, Ayoze ;

Fabre-Pi, Oscar ;

Carolina Lopez-Veloso, Ana ;

Diaz-Nicolas, Santiago ;

Cubero-Gonzalez, Alberto .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2010, 37 (05) :692-693

[7] A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130/0.4) undergoing off pump coronary artery bypass surgery [J].

Chakravarthy, Murali ;

Muniraj, Geetha ;

Patil, Swapnil ;

Suryaprakash, Sharadaprasad ;

Mitra, Sona ;

Shivalingappa, Benak .

ANNALS OF CARDIAC ANAESTHESIA, 2012, 15 (02) :105-110

[8] The Effect of Tranexamic Acid on Blood Loss During Orthognathic Surgery: A Randomized Controlled Trial [J].

Choi, Wing Shan ;

Irwin, Michael G. ;

Samman, Nabil .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2009, 67 (01) :125-133

[9]

Damji KF, 1998, CAN J OPHTHALMOL, V33, P308

[10]

Dodson Thomas B, 2011, J Evid Based Dent Pract, V11, P185, DOI 10.1016/j.jebdp.2011.09.004

← 1 2 3 4 →