Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress

被引：30
作者：
Zhang, Tie-Ning [1 ]
Wang, Wei [1 ]
Yang, Ni [1 ]
Huang, Xin-Mei [2 ,3 ]
Liu, Chun-Feng [1 ]
机构：
[1] China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China
[2] Fudan Univ, Peoples Hosp 5, Dept Endocrinol, Shanghai, Peoples R China
[3] Yale Univ, Sch Med, Dept Obstet & Gynecol, New Haven, CT 06510 USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金;
关键词：
lncRNA; glucose metabolism; lipid metabolism; regulatory role; tissue; cancer; LNCRNA INHIBITS ADIPOGENESIS; SIGNAL-TRANSDUCTION PATHWAY; HEPATIC INSULIN-RESISTANCE; FATTY LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; TRANSCRIPTION FACTORS; EXPRESSION PROFILE; NEGATIVE REGULATOR; CHOLESTEROL EFFLUX;
D O I：
10.3389/fendo.2020.00457
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Long non-coding RNAs (lncRNAs) are a type of non-coding RNA with a length that exceeds 200 nucleotides. Previous studies have shown that lncRNAs play an important role in the pathogenesis of various diseases. Research in both animal models and humans has begun to unravel the profound complexity of lncRNAs and demonstrated that lncRNAs exert direct effects on glucose and lipid metabolism bothin vivoandin vitro. Such research has elucidated the regulatory role of lncRNAs in glucose and lipid metabolism in human disease. lncRNAs mediate glucose and lipid metabolism under physiological and pathological conditions and contribute to various metabolism disorders. This review provides an update on our understanding of the regulatory role of lncRNAs in glucose and lipid metabolism in various diseases. As our understanding of the function of lncRNAs improves, the future is promising for the development of new diagnostic biomarkers that utilize lncRNAs and treatments that target lncRNAs to improve clinical outcomes.
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页数：20
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