A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

被引：67

作者：

He, Huan ^{[1
,2
]}

Li, Dong-Wei ^{[1
,2
]}

Yang, Li-Yun ^{[1
,2
]}

Fu, Li ^{[1
,2
]}

Zhu, Xun-Jin ^{[3
]}

Wong, Wai-Kwok ^{[3
]}

Jiang, Feng-Lei ^{[1
,2
]}

Liu, Yi ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem Mol Sci, State Key Lab Virol, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Coll Chem Mol Sci, Key Lab Analyt Chem Biol & Med MOE, Wuhan 430072, Peoples R China

[3] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

APOPTOSIS; PROBE; PROLIFERATION; DERIVATIVES; METABOLISM; MECHANISMS; LEUKOCYTES; COMPOUND; COMPLEX; DRUGS;

D O I：

10.1038/srep13543

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

引用

页数：10

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