Evaluation of compatibility of tablet excipients and novel synthesized polymer with lamivudine

被引：33
|
作者：
Singh, Akhilesh V. [1 ]
Nath, Lila K. [1 ]
机构：
[1] Dibrugarh Univ, Dept Pharmaceut Sci, Dibrugarh, Assam, India
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2012年 / 108卷 / 01期
关键词：
Lamivudine; Excipients; Cross-linked starch; DSC; FT-IR; DIFFERENTIAL SCANNING CALORIMETRY; KETOPROFEN;
D O I：
10.1007/s10973-011-1650-2
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The present study describes compatibility of anti-HIV drug lamivudine with various selected excipients and a novel synthesized polymer, for the development of its controlled release formulation. Differential scanning calorimetry (DSC), isothermal stability study (ISS) and Fourier transform infrared (FT-IR) spectral analysis were performed to access the compatibility. The compatibility study was performed with various common excipients like spray dried lactose, polyvinyl pyrrolidine K-30, magnesium stearate, talc and a novel synthesized polymer crosslinked sago starch with lamivudine.
引用
收藏
页码：263 / 267
页数：5
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