Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

被引：829
|
作者：
Busche, Marc Aurel [1 ,4 ]
Eichhoff, Gerhard [1 ,4 ]
Adelsberger, Helmuth [1 ,4 ]
Abramowski, Dorothee [2 ]
Wiederhold, Karl-Heinz [2 ]
Haass, Christian [3 ,4 ]
Staufenbiel, Matthias [2 ]
Konnerth, Arthur [1 ,4 ]
Garaschuk, Olga [1 ,4 ]
机构：
[1] Tech Univ Munich, Inst Neurowissensch, D-80802 Munich, Germany
[2] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland
[3] Univ Munich, Dept Biochem, Lab Neurodegenerat Dis Res, Adolf Butenandt Inst, D-80336 Munich, Germany
[4] Ctr Integrated Prot Sci, D-81377 Munich, Germany
来源：
SCIENCE | 2008年 / 321卷 / 5896期
关键词：
D O I：
10.1126/science.1162844
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two- photon Ca(2+) imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca(2+) transients. These "hyperactive" neurons were found exclusively near the plaques of amyloid beta-depositing mice. The hyperactivity appeared to be due to a relative decrease in synaptic inhibition. Thus, we suggest that a redistribution of synaptic drive between silent and hyperactive neurons, rather than an overall decrease in synaptic activity, provides a mechanism for the disturbed cortical function in Alzheimer's disease.
引用
收藏
页码：1686 / 1689
页数：4
相关论文
共 50 条
  • [11] Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models
    Raymond, S. B.
    Kumar, A. T. N.
    Boas, D. A.
    Bacskai, B. J.
    PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (20): : 6201 - 6216
  • [12] C3 is associated with amyloid plaques in the transgenic mouse model of Alzheimer's disease
    Yu, JX
    Brandt, BM
    Hsiao, K
    Cooper, NR
    MOLECULAR IMMUNOLOGY, 1998, 35 (6-7) : 337 - 337
  • [13] Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease
    Weber-Adrian, Danielle
    Kofoed, Rikke Hahn
    Chan, Josephine Wing Yee
    Silburt, Joseph
    Noroozian, Zeinab
    Kuegler, Sebastian
    Hynynen, Kullervo
    Aubert, Isabelle
    THERANOSTICS, 2019, 9 (26): : 8127 - 8137
  • [14] Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
    Melanie Meyer-Luehmann
    Tara L. Spires-Jones
    Claudia Prada
    Monica Garcia-Alloza
    Alix de Calignon
    Anete Rozkalne
    Jessica Koenigsknecht-Talboo
    David M. Holtzman
    Brian J. Bacskai
    Bradley T. Hyman
    Nature, 2008, 451 : 720 - 724
  • [15] Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
    Meyer-Luehmann, Melanie
    Spires-Jones, Tara L.
    Prada, Claudia
    Garcia-Alloza, Monica
    de Calignon, Alix
    Rozkalne, Anete
    Koenigsknecht-Talboo, Jessica
    Holtzman, David M.
    Bacskai, Brian J.
    Hyman, Bradley T.
    NATURE, 2008, 451 (7179) : 720 - U5
  • [16] β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease
    Gunnar K. Gouras
    Tomas T. Olsson
    Oskar Hansson
    Neurotherapeutics, 2015, 12 : 3 - 11
  • [17] β-amyloid Peptides and Amyloid Plaques in Alzheimer's Disease
    Gouras, Gunnar K.
    Olsson, Tomas T.
    Hansson, Oskar
    NEUROTHERAPEUTICS, 2015, 12 (01) : 3 - 11
  • [18] Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease
    Kaneko, Ryusei
    Matsui, Ako
    Watanabe, Mahiro
    Harada, Yoshihiro
    Kanamori, Mitsuhiro
    Awata, Natsumi
    Kawazoe, Mio
    Takao, Tomoaki
    Kobayashi, Yutaro
    Kikutake, Chie
    Suyama, Mikita
    Saito, Takashi
    Saido, Takaomi C.
    Ito, Minako
    INFLAMMATION AND REGENERATION, 2023, 43 (01)
  • [19] Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer’s disease
    Ryusei Kaneko
    Ako Matsui
    Mahiro Watanabe
    Yoshihiro Harada
    Mitsuhiro Kanamori
    Natsumi Awata
    Mio Kawazoe
    Tomoaki Takao
    Yutaro Kobayashi
    Chie Kikutake
    Mikita Suyama
    Takashi Saito
    Takaomi C. Saido
    Minako Ito
    Inflammation and Regeneration, 43
  • [20] In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of Alzheimer's Disease Mouse Model
    Chen, Congping
    Liang, Zhuoyi
    Zhou, Biao
    Li, Xuesong
    Lui, Caleb
    Ip, Nancy Y.
    Qu, Jianan Y.
    ACS CHEMICAL NEUROSCIENCE, 2018, 9 (12): : 3128 - 3136
12345