Effects of Nanogold on the Alleviation of Carbon Tetrachloride-Induced Hepatic Injury in Rats

被引：13

作者：

Chen, Yi-Peng ^{[2
]}

Dai, Zong-Her ^{[2
]}

Liu, Pan-Chen ^{[3
]}

Chuu, Jiunn-Jye ^{[2
]}

Lee, Kuo-Yang ^{[2
]}

Lee, Shun-Lai ^{[2
]}

Chen, Yun-Ju ^{[1
]}

机构：

[1] So Taiwan Univ, Coll Humanities & Social Sci, Dept Child Care, Tainan 71005, Taiwan

[2] So Taiwan Univ, Coll Engn, Dept Biotechnol, Tainan 71005, Taiwan

[3] Natl Chung Hsing Univ, Coll Vet Med, Dept Vet Med, Taichung 40227, Taiwan

来源：

CHINESE JOURNAL OF PHYSIOLOGY | 2012年 / 55卷 / 05期

关键词：

alanine aminotransferase; aspartate aminotransferase; hepatic injury; IL-10; nanogold; COLLOIDAL GOLD; CELLS; TRANSPORT; EXTRACT;

D O I：

10.4077/CJP.2012.BAA064

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Gold particles have been used in complementary medicine for decades, and many beneficial effects have been reported. Our present study sought to evaluate the therapeutic effects of nanogold in carbon tetrachloride (CCl4)-injured liver of rats. Male SD rats were subjected to liver injury induction by CCl4, then the rats were fed with zero to high dose (0, 1, 5 or 10 ppm) of nanogold water every day for 4 weeks. Biochemical analyses on liver functions were then performed to evaluate the therapeutic effects of nanogold. Our results revealed that gold nanoparticles lowered serum aspartate aminotransaminase (AST) and alanine aminotransferase and exerted serum total protein-recovering effects, which might be partially associated with the elevation of anti-inflammatory cytokine IL-10 level. In addition, serum triglyceride level fell after continuous ingestion of nanogold. Finally, the experimental animals recovered body weight after 4 weeks of nanogold ingestion. This is the first report indicating inflammation-alleviating effects of nanogold on hepatic injury.

引用

页码：331 / 336

页数：6

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