Upconversion nanoprobes for biodetections

被引:119
作者
Li, Zhenhua [1 ,2 ]
Yuan, Hang [1 ,2 ]
Yuan, Wei [1 ,2 ]
Su, Qianqian [1 ,2 ,3 ]
Li, Fuyou [1 ,2 ]
机构
[1] Fudan Univ, Dept Chem, State Key Lab Mol Engn Polymers, 220 Handan Rd, Shanghai 200433, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, 220 Handan Rd, Shanghai 200433, Peoples R China
[3] Shanghai Univ, Inst Nanochem & Nanobiol, Shangda Rd, Shanghai 200444, Peoples R China
基金
国家重点研发计划; 美国国家科学基金会;
关键词
Upconversion nanoparticles; Detections; Lanthanide; Energy transfer; RESONANCE ENERGY-TRANSFER; IN-VIVO DETECTION; UPCONVERTING LUMINESCENT NANOPARTICLES; ULTRASENSITIVE DETECTION; NANO-BIOPROBES; QUANTUM DOTS; LIVING CELLS; ON PROBE; FLUORESCENCE; LRET;
D O I
10.1016/j.ccr.2017.06.025
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Lanthanide-doped upconversion nanomaterials that convert low energy excitation wavelength to high energy emission have attracted considerable attention due to the advantages of high penetration depth and high resistance to autofluorescence interference capability. This review highlights the literature of the past several years covering recent advances of upconversion nanoprobes for biodetection. We begin by discussions of the key points in fabrication of lanthanide-activated nanoprobes. We further conduct a careful evaluation of various detection applications of upconversion nanoprobes, including temperature, ions, small molecules, DNA, enzyme, virus, and etc. We finish the discussion by assessing current challenges and future prospects of upconversion nanoprobes for fundamental studies and clinical applications. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:155 / 168
页数:14
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