The role of UV photolysis and molecular transport in the generation of reactive species in a tissue model with a cold atmospheric pressure plasma jet
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作者:
Ghimire, Bhagirath
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Kwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South KoreaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Ghimire, Bhagirath
[1
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Szili, Endre J.
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机构:
Univ South Australia, Future Ind Inst, Adelaide, SA 5095, AustraliaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Szili, Endre J.
[2
]
Lamichhane, Pradeep
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Kwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South KoreaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Lamichhane, Pradeep
[1
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Short, Robert D.
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Univ South Australia, Future Ind Inst, Adelaide, SA 5095, Australia
Univ Lancaster, Mat Sci Inst, Lancaster LA1 4YW, England
Univ Lancaster, Dept Chem, Lancaster LA1 4YW, EnglandKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Short, Robert D.
[2
,3
,4
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Lim, Jun Sup
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Kwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South KoreaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Lim, Jun Sup
[1
]
Attri, Pankaj
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Univ Antwerp, Dept Chem, Res Grp PLASMANT, B-2610 Antwerp, BelgiumKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Attri, Pankaj
[5
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Masur, Kai
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INP Greifswald eV, Felix Hausdorff Str 2, D-17489 Greifswald, GermanyKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Masur, Kai
[6
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Weltmann, Klaus-Dieter
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INP Greifswald eV, Felix Hausdorff Str 2, D-17489 Greifswald, GermanyKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Weltmann, Klaus-Dieter
[6
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Hong, Sung-Ha
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Univ South Australia, Future Ind Inst, Adelaide, SA 5095, AustraliaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Hong, Sung-Ha
[2
]
Choi, Eun Ha
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Kwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South KoreaKwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
Choi, Eun Ha
[1
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机构:
[1] Kwangwoon Univ, Dept Elect & Biol Phys, Plasma Biosci Res Ctr, Seoul 01897, South Korea
[2] Univ South Australia, Future Ind Inst, Adelaide, SA 5095, Australia
[3] Univ Lancaster, Mat Sci Inst, Lancaster LA1 4YW, England
[4] Univ Lancaster, Dept Chem, Lancaster LA1 4YW, England
Cold atmospheric pressure plasma jets (plasma) operated in ambient air provide a rich source of reactive oxygen and nitrogen species (RONS), which are known to influence biological processes important in disease. In the plasma treatment of diseased tissue such as subcutaneous cancer tumors, plasma RONS need to first traverse an interface between the plasma-skin surface and second be transported to millimeter depths in order to reach deep-seated diseased cells. However, the mechanisms in the plasma generation of RONS within soft tissues are not understood. In this study, we track the plasma jet delivery of RONS into a tissue model target and we delineate two processes: through target delivery of RONS generated (primarily) in the plasma jet and in situ RONS generation by UV photolysis within the target. We demonstrate that UV photolysis promotes the rapid generation of RONS in the tissue model target's surface after which the RONS are transported to millimeter depths via a slower molecular process. Our results imply that the flux of UV photons from plasma jets is important for delivering RONS through seemingly impenetrable barriers such as skin. The findings have implications not only in treatments of living tissues but also in the functionalization of soft hydrated biomaterials such as hydrogels and extracellular matrix derived tissue scaffolds.
机构:
Univ Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Kondeti, V. S. Santosh K.
Phan, Chi Q.
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Univ Minnesota, Dept Microbiol & Immunol, Microbiol Res Facil, 689 SE,23rd Ave, Minneapolis, MN 55455 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Phan, Chi Q.
Wende, Kristian
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机构:
Leibniz Inst Plasma Sci & Technol EV INP Greifswa, ZIK Plasmatis, Felix Hausdorff Str 2, D-17489 Greifswald, GermanyUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Wende, Kristian
Jablonowski, Helena
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机构:
Leibniz Inst Plasma Sci & Technol EV INP Greifswa, ZIK Plasmatis, Felix Hausdorff Str 2, D-17489 Greifswald, GermanyUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Jablonowski, Helena
Gangal, Urvashi
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Univ Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Gangal, Urvashi
Granick, Jennifer L.
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Univ Minnesota, Dept Vet Clin Sci, Vet Med Ctr 339, 1352 Boyd Ave, St Paul, MN 55108 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Granick, Jennifer L.
Hunter, Ryan C.
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Univ Minnesota, Dept Microbiol & Immunol, Microbiol Res Facil, 689 SE,23rd Ave, Minneapolis, MN 55455 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
Hunter, Ryan C.
Bruggeman, Peter J.
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Univ Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USAUniv Minnesota, Dept Mech Engn, 111 Church St SE, Minneapolis, MN 55455 USA
机构:
Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USAUniv Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
Luan, Pingshan
Oehrlein, Gottlieb S.
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Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USAUniv Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA
Oehrlein, Gottlieb S.
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A,
2019,
37
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