Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments

被引：9

作者：

Banerjee, A. ^{[1
]}

Prante, O. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Nucl Med Clin, Lab Mol Imaging & Radiochem, D-91054 Erlangen, Germany

来源：

CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 23期

关键词：

Dopamine; D2; D3; D4; dopamine receptor; selectivity; subtype-selectivity; positron emission tomography; PET; radioligand; PET ligand; radiopharmaceutical; F-18; C-11; POSITRON-EMISSION-TOMOGRAPHY; IN-VITRO EVALUATION; HIGH-AFFINITY STATE; D-4; RECEPTOR; HUMAN-BRAIN; PRIMATE BRAIN; RAT-BRAIN; POTENTIAL RADIOTRACER; CELLULAR-DISTRIBUTION; NONHUMAN-PRIMATES;

D O I：

10.2174/092986712802002518

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents a general overview of the subtype-selective dopamine receptor radioligands for in vivo imaging of dopamine receptor expression by positron emission tomography (PET). Besides the C-11- and F-18-labeled radioligands which are already in clinical use, a summary of subtype-selective radioligands which had been studied in vitro and in vivo is provided, which shines light onto the current status and recent developments in this field of radiopharmaceutical research.

引用

页码：3957 / 3966

页数：10

共 105 条

[1] The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects [J].

Aalto, Sargo ;

Hirvonen, Jussi ;

Kaasinen, Valtteri ;

Hagelberg, Nora ;

Kajander, Jaana ;

Nagren, Kjell ;

Seppala, Timo ;

Rinne, Juha O. ;

Scheinin, Harry ;

Hietala, Jarmo .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 (03) :475-483

[2] Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response -: A double-blind PET study in schizophrenia [J].

Agid, Ofer ;

Mamo, David ;

Ginovart, Nathalie ;

Vitcu, Irina ;

Wilson, Alan A. ;

Zipursky, Robert B. ;

Kapur, Shitij .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (06) :1209-1215

[3] CHARACTERIZATION OF BINDING OF [H-3]PD-128907, A SELECTIVE DOPAMINE D-3 RECEPTOR AGONIST LIGAND, TO CHO-K1 CELLS [J].

AKUNNE, HC ;

TOWERS, P ;

ELLIS, GJ ;

DIJKSTRA, D ;

WIKSTROM, H ;

HEFFNER, TG ;

WISE, LD ;

PUGSLEY, TA .

LIFE SCIENCES, 1995, 57 (15) :1401-1410

[4] Cellular distribution of the rat D-4 dopamine receptor protein in the CNS using anti-receptor antisera [J].

Ariano, MA ;

Wang, J ;

Noblett, KL ;

Larson, ER ;

Sibley, DR .

BRAIN RESEARCH, 1997, 752 (1-2) :26-34

[5] [F-18] N-METHYLSPIROPERIDOL - THE RADIOLIGAND OF CHOICE FOR PETT STUDIES OF THE DOPAMINE RECEPTOR IN HUMAN-BRAIN [J].

ARNETT, CD ;

FOWLER, JS ;

WOLF, AP ;

SHIUE, CY ;

MCPHERSON, DW .

LIFE SCIENCES, 1985, 36 (14) :1359-1366

[6] Dopamine D1 receptors and age differences in brain activation during working memory [J].

Backman, Lars ;

Karlsson, Sari ;

Fischer, Hakan ;

Karlsson, Per ;

Brehmer, Yvonne ;

Rieckmann, Anna ;

MacDonald, Stuart W. S. ;

Farde, Lars ;

Nyberg, Lars .

NEUROBIOLOGY OF AGING, 2011, 32 (10) :1849-1856

[7] Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies [J].

Bennacef, Idriss ;

Salinas, Cristian A. ;

Bonasera, Thomas A. ;

Gunn, Roger N. ;

Audrain, Helene ;

Jakobsen, Steen ;

Nabulsi, Nabeel ;

Weinzimmer, David ;

Carson, Richard E. ;

Huang, Yiyun ;

Holmes, Ian ;

Micheli, Fabrizio ;

Heidbreder, Christian ;

Gentile, Gabriella ;

Rossi, Tino ;

Laruelle, Marc .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) :5056-5059

[8] Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline (+)-[11C]A-69024 and positron emission tomography [J].

Besret, Laurent ;

Dolle, Frederic ;

Herard, Anne-Sophie ;

Guillermier, Martine ;

Demphel, Stephane ;

Hinnen, Francoise ;

Coulon, Christine ;

Ottaviani, Michele ;

Bottlaender, Michel ;

Hantraye, Philippe ;

Kassiou, Michael .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (07) :2811-2819

[9]

Boy C, 1998, SYNAPSE, V30, P341

[10] MODULATION OF COCAINE SELF-ADMINISTRATION IN THE RAT THROUGH D-3 DOPAMINE-RECEPTORS [J].

CAINE, SB ;

KOOB, GF .

SCIENCE, 1993, 260 (5115) :1814-1816

← 1 2 3 4 5 6 7 8 9 10 →