Anti-inflammatory effects of low-dose radiotherapy Indications, dose, and radiobiological mechanisms involved

被引：119

作者：

Arenas, M. ^{[1
]}

Sabater, S. ^{[2
]}

Hernandez, V. ^{[3
]}

Rovirosa, A. ^{[4
]}

Lara, P. C. ^{[5
]}

Biete, A. ^{[4
]}

Panes, J. ^{[6
]}

机构：

[1] URV, IISPV, Dept Radiat Oncol, Hosp Univ St Joan de Reus, Reus 43200, Spain

[2] Complejo Hosp Univ Albacete, Dept Radiat Oncol, Albacete, Spain

[3] Hosp Univ St Joan de Reus, IISPV, Dept Phys, Tarragona, Spain

[4] UB, IDIBAPS, Hosp Clin Barcelona, Dept Radiat Oncol, Barcelona, Spain

[5] Univ Las Palmas Gran Canaria LPGC, Hosp Univ Dr Negrin, Dept Radiat Oncol, Las Palmas Gran Canaria, Spain

[6] UB, IDIBAPS, Hosp Clin Barcelona, Dept Gastroenterol, Barcelona, Spain

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2012年 / 188卷 / 11期

关键词：

Low-dose radiotherapy; Leukocyte; Endothelium; Adhesion molecules; Benign diseases; LEUKOCYTE/ENDOTHELIAL CELL-ADHESION; ADJUVANT-INDUCED ARTHRITIS; BLOOD MONONUCLEAR-CELLS; ATOMIC-BOMB SURVIVORS; LINEAR NO-THRESHOLD; PAINFUL HEEL SPURS; RADIATION-THERAPY; IONIZING-RADIATION; X-IRRADIATION; IN-VITRO;

D O I：

10.1007/s00066-012-0170-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Low-dose radiotherapy (LD-RT) has been used for several benign diseases, including arthrodegenerative and inflammatory pathologies. Despite its effectiveness in clinical practice, little is known about the mechanisms through which LD-RT modulates the various phases of the inflammatory response and about the optimal dose fractionation. The objective of this review is to deepen knowledge about the most effective LD-RT treatment schedule and radiobiological mechanisms underlying the anti-inflammatory effects of LD-RT in various in vitro experiments, in vivo studies, and clinical studies.

引用

页码：975 / 981

页数：7

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