Neuroprotective Effect of Natural Products Against Alzheimer's Disease

被引：202
作者：
Essa, Musthafa M. [1 ,2 ,3 ]
Vijayan, Reshmi K. [2 ]
Castellano-Gonzalez, Gloria [1 ,4 ]
Memon, Mustaq A. [5 ]
Braidy, Nady [1 ,6 ]
Guillemin, Gilles J. [1 ,7 ]
机构：
[1] Univ New S Wales, Neuroinflammat Grp, Dept Pharmacol, Sch Med Sci, Sydney, NSW 2052, Australia
[2] Sultan Qaboos Univ, Coll Agr & Marine Sci, Dept Food Sci & Nutr, Muscat, Oman
[3] NYSIBR, Dev Neurosci Lab, Staten Isl, NY 10314 USA
[4] St Vincents Ctr Appl Med Res, Neuroinflammat Grp, Sydney, NSW, Australia
[5] Washington State Univ, Pullman, WA 99164 USA
[6] Univ New S Wales, Fac Med, Sch Psychiat, Sydney, NSW, Australia
[7] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Behav Med, Muscat, Oman
来源：
NEUROCHEMICAL RESEARCH | 2012年 / 37卷 / 09期
关键词：
Natural products; Alzheimer's disease; Antioxidant polyphenols; Neuroprotection; Cell signalling; GINKGO-BILOBA EXTRACT; AMYLOID PRECURSOR PROTEIN; RAT PHEOCHROMOCYTOMA CELLS; INDUCED OXIDATIVE INJURY; GREEN TEA POLYPHENOLS; GRAPE SEED EXTRACT; MOUSE MODEL; IN-VIVO; BLUEBERRY SUPPLEMENTATION; SCROPHULARIA-BUERGERIANA;
D O I：
10.1007/s11064-012-0799-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially hinder neurodegeneration, and improve memory and cognitive function. Nuts such as walnut have also demonstrated neuroprotective effect against AD. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.
引用
收藏
页码：1829 / 1842
页数：14
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