Putative tumor suppression function of SIRT6 in endometrial cancer

被引：36
作者：
Fukuda, Tomohiko [1 ]
Wada-Hiraike, Osamu [1 ]
Oda, Katsutoshi [1 ]
Tanikawa, Michihiro [1 ]
Makii, Chinami [1 ]
Inaba, Kanako [1 ]
Miyasaka, Aid [1 ]
Miyamoto, Yuichiro [1 ]
Yano, Tetsu [3 ]
Maeda, Daichi [2 ]
Sasaki, Takeshi [2 ]
Kawana, Kei [1 ]
Fukayama, Masashi [2 ]
Osuga, Yutaka [1 ]
Fujii, Tomoyuki [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Obstet & Gynecol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138655, Japan
[3] Natl Ctr Global Hlth & Med, Dept Obstet & Gynecol, Shinjyuku Ku, Tokyo 1628655, Japan
来源：
FEBS LETTERS | 2015年 / 589卷 / 17期
关键词：
Endometrial cancer; SIRT6; Survivin; Apoptosis; YM155; HISTONE DEACETYLASE SIRT6; SMALL-MOLECULE SUPPRESSOR; PHASE-II; SURVIVIN; YM155; GENE; EXPRESSION; APOPTOSIS; STRESS; RISK;
D O I：
10.1016/j.febslet.2015.06.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
SIRT6, a member of the sirtuin family, has been identified as a candidate tumor suppressor. To pursue the role of SIRT6 in endometrial cancer, we investigated the anti-tumorigenic function of SIRT6. The expression of SIRT6 negatively affected the proliferation of AN3CA and KLE endometrial cancer cells. Increased expression of SIRT6 resulted in the induction of apoptosis by repressing the expression of the anti-apoptotic protein survivin. Consistent with this result, a survivin inhibitor YM155 efficiently inhibited cellular proliferation and induced apoptosis. These results revealed that SIRT6 might function as a tumor suppressor of endometrial cancer cells. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2274 / 2281
页数：8
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