Role of emmprin/CD147 in tissue remodeling

被引：57

作者：

Huet, Eric

Gabison, Eric E. ^{[2
,3
]}

Mourah, Samia ^{[4
]}

Menashi, Suzanne ^{[1
]}

机构：

[1] Univ Paris 12, CNRS, CRRET Lab, UMR 7149, F-94010 Creteil, France

[2] Fdn Adolphe De Rothschild, Dept Ophthalmol, Paris, France

[3] Hop Xavier Bichat, Paris, France

[4] Hop St Louis, Pharmacol Lab, Paris, France

来源：

CONNECTIVE TISSUE RESEARCH | 2008年 / 49卷 / 3-4期

关键词：

emmprin; CD147; matrix metalloproteinase; urokinase-type plasminogen activator; tissue remodeling; cancer;

D O I：

10.1080/03008200802151722

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Emmprin/CD147 is a cell membrane glycoprotein that belongs to the Ig superfamily and is involved in numerous physiological and pathological systems. Through its ability to interact with multiple partners within the cell surface and its potential to regulate the expression of several targets within the cell, emmprin may have different functions depending on the cell or tissue type. However, its role in tissue remodeling remains the most clearly demonstrated. Emmprin is able to induce, in the same cellular model, both the matrix metalloproteinases and the serine protease urokinase plasminogen activator, whose concerted action in the breakdown of the extracellular matrix (ECM) during various physiopathological situations has been reported. In addition, emmprin also promotes myofibroblasts' differentiation and tissue contraction through the induction of alpha smooth muscle actin, thus expanding on the mechanism by which emmprin remodels ECM.

引用

页码：175 / 179

页数：5

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