Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

被引：14

作者：

Zhang, Haili ^{[1
,2
,3
]}

Yang, Dong ^{[2
,3
]}

Wang, Haijuan ^{[2
,3
]}

Wen, Shuxin ^{[1
]}

Liu, Jian ^{[2
,3
]}

Luan, Qingchun ^{[2
,3
]}

Huang, Yixuan ^{[2
,3
]}

Wang, Binquan ^{[1
]}

Lin, Chen ^{[2
,3
]}

Qian, Haili ^{[2
,3
]}

机构：

[1] Shanxi Med Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Taiyuan 030001, Shanxi, Peoples R China

[2] Chinese Acad Med Sci, Canc Hosp, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

ONCOLOGY LETTERS | 2014年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

metastasis-associated gene 1; laryngeal squamous cell carcinoma; invasion; metastasis; ESTROGEN-RECEPTOR-ALPHA; MTA1; MESSENGER-RNA; LUNG-CANCER; HISTONE DEACETYLASE; BREAST-CANCER; IN-VITRO; EXPRESSION; PROTEIN-1; PROGRESSION; INVASIVENESS;

D O I：

10.3892/ol.2013.1729

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP-2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.

引用

页码：399 / 404

页数：6

共 37 条

[1] RETRACTED: Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis (Retracted article. See vol. 142, pg. 1388, 2015) [J].