Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity

被引：43

作者：

Boufadi, Yasmina Mokhtaria ^{[1
,2
]}

Soubhye, Jalal ^{[2
]}

Riazi, Ali ^{[1
]}

Rousseau, Alexandre ^{[3
]}

Vanhaeverbeek, Michel ^{[3
]}

Neve, Jean ^{[2
]}

Boudjeltia, Karim Zouaoui ^{[3
]}

Van Antwerpen, Pierre ^{[2
,4
]}

机构：

[1] Univ Abdelhamid Ibn Badis, Fac Nat Sci & Life, Lab Beneficial Microorganisms Funct Food & Hlth L, Mostaganem 27000, Algeria

[2] Univ Libre Bruxelles, Fac Pharm, Lab Pharmaceut Chem, B-1050 Brussels, Belgium

[3] Univ Libre Bruxelles, A Vesale Hosp, Expt Med Lab, CHU Charleroi, B-6110 Montignies le Tilleul, Belgium

[4] Univ Libre Bruxelles, Analyt Platform Fac Pharm, B-1050 Brussels, Belgium

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 02期

关键词：

propolis; oxidative stress; free radical scavenging; myeloperoxidase inhibition; LDL oxidation inhibition; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HUMAN ATHEROSCLEROTIC LESIONS; CHEMICAL-COMPOSITION; OXIDATIVE STRESS; CHLORINATING ACTIVITY; BRAZILIAN PROPOLIS; HYPOCHLOROUS ACID; ASCORBIC-ACID; TOTAL PHENOLS; PLANT-ORIGIN;

D O I：

10.3390/ijms15022327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Because propolis contains many types of antioxidant compounds such as polyphenols and flavonoids, it can be useful in preventing oxidative damages. Ethyl acetate extracts of propolis from several Algerian regions show high activity by scavenging free radicals, preventing lipid peroxidation and inhibiting myeloperoxidase (MPO). By fractioning and assaying ethyl acetate extracts, it was observed that both polyphenols and flavonoids contribute to these activities. A correlation was observed between the polyphenol content and the MPO inhibition. However, it seems that kaempferol, a flavonoid, contributes mainly to the MPO inhibition. This molecule is in a high amount in the ethyl acetate extract and demonstrates the best efficiency towards the enzyme with an inhibiting concentration at 50% of 4 +/- 2 M.

引用

页码：2327 / 2345

页数：19

共 57 条

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