Microbial reduction of ethyl 2-oxo-4-phenylbutyrate.: Searching for R-enantioselectivity.: New access to the enalapril like ACE inhibitors

被引：22
作者：
Bergo de Lacerda, Paulo S. [1 ]
Ribeiro, Joyce Benzaquem
Leite, Selma G. F.
Ferrara, Maria Antonieta
Coelho, Ricardo B.
Bon, Elba P. S.
Luiz da Silva Lima, Edson
Antunes, O. A. C.
机构：
[1] FarManguinhos Fundacao Oswaldo Cruz, BR-20000 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Quim, BR-21945970 Rio de Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Escola Quim, BR-21945970 Rio de Janeiro, Brazil
来源：
TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 08期
关键词：
D O I：
10.1016/j.tetasy.2006.04.008
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Herein, different microorganisms were tested in the enantio selective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：1186 / 1188
页数：3
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