Personality traits and vulnerability or resilience to substance use disorders

被引：106

作者：

Belcher, Annabelle M. ^{[1
]}

Volkow, Nora D. ^{[2
]}

Moeller, F. Gerard ^{[3
,4
]}

Ferre, Sergi ^{[1
]}

机构：

[1] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[2] NIDA, NIH, Bethesda, MD 20892 USA

[3] Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA 23219 USA

[4] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol & Toxicol, Richmond, VA 23219 USA

来源：

TRENDS IN COGNITIVE SCIENCES | 2014年 / 18卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; INDIVIDUAL-DIFFERENCES; RECEPTOR AVAILABILITY; RESPONSE-INHIBITION; BLINK RATES; DOPAMINE; POLYMORPHISM; COCAINE; EXTROVERSION; ADDICTION;

D O I：

10.1016/j.tics.2014.01.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Clear evidence supports a genetic basis for substance use disorders (SUD). Yet, the search to identify individual gene contributions to SUD has been unsuccessful. Here, we argue for the study of endophenotypes within the frame of individual differences, and identify three high-order personality traits that are tied to specific brain systems and genes, and that offer a tractable approach to studying SUD. These personality traits, and the genes that moderate them, interact dynamically with the environment and with the drugs themselves to determine ultimately an individual's vulnerability or resilience to developing SUD.

引用

页码：211 / 217

页数：7

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