Application of Hydrolase Catalytic Promiscuity in Organic Synthesis

被引:4
作者
Ge, Xin [1 ]
Lai, Yifeng [1 ,2 ]
Chen, Xinzhi [1 ]
机构
[1] Zhejiang Univ, Ministiy Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China
[2] Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Hangzhou 310012, Zhejiang, Peoples R China
关键词
hydrolase; promiscuity; Michael addition; aldol reaction; three-component reaction; CARBON BOND FORMATION; ONE-POT SYNTHESIS; MICHAEL ADDITION; BIOCATALYTIC PROMISCUITY; ALKALINE PROTEASE; ENZYME PROMISCUITY; SECONDARY-AMINES; LIPASE; DERIVATIVES; CONDENSATION;
D O I
10.6023/cjoc201212048
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
This review introduces the mechanism of hydrolase promiscuity. Several applications of hydrolase catalytic promiscuity in unit reaction, two-step reaction and three-component reaction are summarized, especially for addition, aldol reaction, and Knoevenagel reaction.
引用
收藏
页码:1686 / 1696
页数:11
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