Pain management in patients with malignant mesothelioma: challenges and solutions

被引:11
作者
Saunders, J. [1 ]
Ashton, M. [1 ,2 ]
Hall, C. [3 ,4 ]
Laird, B. [3 ,4 ]
MacLeod, N. [1 ]
机构
[1] Beatson West Scotland Canc Ctr, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland
[2] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland
[3] Univ Edinburgh, Inst Genet & Mol Med, Edinburgh EH4 2XR, Midlothian, Scotland
[4] St Columbas Hosp, Edinburgh EHS 3RW, Midlothian, Scotland
关键词
malignant; pleural; mesothelioma; pain; radiotherapy; PLEURAL-MESOTHELIOMA; CANCER PAIN; OPEN-LABEL; EXTRAPLEURAL PNEUMONECTOMY; RANDOMIZED-TRIAL; RADIOTHERAPY; PREVENTION; CISPLATIN; SURGERY; OPIOIDS;
D O I
10.2147/LCTT.S192558
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Malignant pleural mesothelioma (MPM) is an aggressive cancer with a considerable symptom burden and poor prognosis. Focus on maintaining patients' quality of life and pain control is therefore paramount. Pain management in MPM is complex due to its multifactorial etiology resulting from direct tumor infiltration of the surrounding soft tissue, bone, and encasement of the intercostal nerves. A variety of treatment modalities, including pharmacological and non-pharmacological options, are often required to achieve adequate pain control in this challenging disease. This review article examines the current challenges and solutions available for pain management in MPM.
引用
收藏
页码:37 / 46
页数:10
相关论文
共 60 条
[1]   Ultrasound-Guided Radiofrequency Treatment of Intercostal Nerves for the Prevention of Incidental Pain Arising Due to Rib Metastasis: A Prospective Study [J].
Ahmed, Arif ;
Bhatnagar, Sushma ;
Khurana, Deepa ;
Joshi, Saurabh ;
Thulkar, Sanjay .
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE, 2017, 34 (02) :115-124
[2]   Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): preliminary results from a non-randomised, open-label, phase 1b trial [J].
Alley, Evan W. ;
Lopez, Juanita ;
Santoro, Armando ;
Morosky, Anne ;
Saraf, Sanatan ;
Piperdi, Bilal ;
van Brummelen, Emilie .
LANCET ONCOLOGY, 2017, 18 (05) :623-630
[3]   Symptomatic and Quality of Life Changes After Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma [J].
Ambrogi, Vincenzo ;
Mineo, Davide ;
Gatti, Antonio ;
Pompeo, Eugenio ;
Mineo, Tommaso C. .
JOURNAL OF SURGICAL ONCOLOGY, 2009, 100 (03) :199-204
[4]  
[Anonymous], COCHRANE DATABASE SY
[5]   SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma [J].
Ashton, M. ;
O'Rourke, N. ;
Macleod, N. ;
Laird, B. ;
Stobo, J. ;
Kelly, C. ;
Alexander, L. ;
Franks, K. ;
Moore, K. ;
Currie, S. ;
Valentine, R. ;
Chalmers, A. J. .
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY, 2018, 8 :45-49
[6]   Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upaEuro [J].
Baas, P. ;
Fennell, D. ;
Kerr, K. M. ;
Van Schil, P. E. ;
Haas, R. L. ;
Peters, S. .
ANNALS OF ONCOLOGY, 2015, 26 :V31-V39
[7]   Protocol for PIT: a phase III trial of prophylactic irradiation of tracts in patients with malignant pleural mesothelioma following invasive chest wall intervention [J].
Bayman, N. ;
Ardron, D. ;
Ashcroft, L. ;
Baldwin, D. R. ;
Booton, R. ;
Darlison, L. ;
Edwards, J. G. ;
Lang-Lazdunski, L. ;
Lester, J. F. ;
Peake, M. ;
Rintoul, R. C. ;
Snee, M. ;
Taylor, P. ;
Lunt, C. ;
Faivre-Finn, C. .
BMJ OPEN, 2016, 6 (01)
[8]   Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review [J].
Bennett, Michael I. .
PALLIATIVE MEDICINE, 2011, 25 (05) :553-559
[9]   Current treatments and trials in malignant pleural mesothelioma [J].
Bibby, Anna C. ;
Maskell, Nick A. .
CLINICAL RESPIRATORY JOURNAL, 2018, 12 (07) :2161-2169
[10]   PREVENTION OF MALIGNANT SEEDING AFTER INVASIVE DIAGNOSTIC PROCEDURES IN PATIENTS WITH PLEURAL MESOTHELIOMA - A RANDOMIZED TRIAL OF LOCAL RADIOTHERAPY [J].
BOUTIN, C ;
REY, F ;
VIALLAT, JR .
CHEST, 1995, 108 (03) :754-758