Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes

被引：46
|
作者：
Wiedemann, SH
Bergman, RG [1 ]
Eman, JA
机构：
[1] Univ Calif Berkeley, Dept Chem, Ctr New Direct Organ Synth, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Chem Sci, Berkeley, CA 94720 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 10期
关键词：
D O I：
10.1021/ol049417q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas.
引用
收藏
页码：1685 / 1687
页数：3
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