The epidemiology of malignant mesothelioma in women: gender differences and modalities of asbestos exposure

被引：63

作者：

Marinaccio, Alessandro ^{[1
]}

Corfiati, Marisa ^{[1
]}

Binazzi, Alessandra ^{[1
]}

Di Marzio, Davide ^{[1
]}

Scarselli, Alberto ^{[1
]}

Ferrante, Pierpaolo ^{[1
]}

Bonafede, Michela ^{[1
]}

Verardo, Marina ^{[2
]}

Mirabelli, Dario ^{[3
,4
]}

Gennaro, Valerio ^{[5
]}

Mensi, Carolina ^{[6
,7
]}

Schallemberg, Gert ^{[8
]}

Mazzoleni, Guido ^{[9
]}

Merler, Enzo ^{[10
]}

Girardi, Paolo ^{[10
]}

Negro, Corrado ^{[11
]}

D'Agostin, Flavia ^{[11
]}

Romanelli, Antonio ^{[12
]}

Chellini, Elisabetta ^{[13
]}

Silvestri, Stefano ^{[14
]}

Pascucci, Cristiana ^{[15
]}

Calisti, Roberto ^{[15
]}

Stracci, Fabrizio ^{[16
]}

Romeo, Elisa ^{[17
]}

Ascoli, Valeria ^{[18
]}

Trafficante, Luana ^{[19
]}

Carrozza, Francesco ^{[20
]}

Angelillo, Italo Francesco ^{[21
]}

Cavone, Domenica ^{[22
]}

Cauzillo, Gabriella ^{[23
]}

Tallarigo, Federico ^{[24
]}

Tumino, Rosario ^{[25
,26
]}

Melis, Massimo ^{[27
]}

Iavicoli, Sergio ^{[1
]}

机构：

[1] Italian Workers Compensat Author INAIL, Dept Hyg & Epidemiol, Occupat & Environm Med, Rome, Italy

[2] Reg Operating Ctr Valle dAosta COR Valle dAosta, Valle dAosta Hlth Local Unit, Aosta, Italy

[3] Univ Turin, Unit Canc Prevent, COR Piedmont, Turin, Italy

[4] CPO Piemonte, Turin, Italy

[5] Osped Univ San Martino, Natl Canc Res Inst IST, COR Liguria, UO Epidemiol,IRCS Az, Genoa, Italy

[6] Osped Maggiore Policlin, Dept Prevent Med, COR Lombardy, Fdn IRCCS Ca Granda, Milan, Italy

[7] Univ Milan, Milan, Italy

[8] COR Prov Trento, Prov Unit Hlth Hyg & Occupat Med, Trento, Italy

[9] COR Prov Bolzano, Alto Adige Hlth Local Unit, Bolzano, Italy

[10] COR Veneto, Dept Prevent, Occupat Hlth Unit, Padua, Italy

[11] Univ Trieste, Clin Unit Occupat Med, COR Friuli Venezia Giulia, Trieste Gen Hosp, Trieste, Italy

[12] COR Emilia Romagna, Hlth Local Unit, Dept Publ Hlth, Reggio Emilia, Italy

[13] COR Tuscany, Canc Prevent & Res Inst, Unit Environm & Occupat Epidemiol, Florence, Italy

[14] Canc Prevent & Res Inst, Florence, Italy

[15] Univ Camerino, COR Marche, Hygienist Environm & Hlth Sci Dept, Sch Sci drug & Prod Hlth, Camerino, Italy

[16] Univ Perugia, COR Umbria, Dept Hyg & Publ Hlth, Perugia, Italy

[17] COR Lazio, Dept Epidemiol, Rome, Lazio Region, Italy

[18] Univ Roma La Sapienza, COR Lazio, Dept Expt Med, Rome, Italy

[19] COR Abruzzo, Occupat Med Unit, Hlth Local Unit, Pescara, Italy

[20] Cardarelli Hosp, COR Molise, Oncol Unit, Campobasso, Italy

[21] Univ Naples 2, COR Campania, Dept Expt Med, Naples, Italy

[22] Univ Bari, COR Puglia, Sect Occupat Med B Ramazzini, Dept Interdisciplinary Med, Florence, Italy

[23] COR Basilicata, Epidemiol Reg Ctr, Potenza, Italy

[24] COR Calabria, Publ Hlth Unit, Crotone, Italy

[25] COR Sicily, Canc Registry ASP Ragusa, Crotone, Italy

[26] COR Sicily, Sicily Reg Epidemiol Observ, Rome, Italy

[27] COR Sardegna, Reg Epidemiol Ctr, Cagliari, Italy

来源：

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2018年 / 75卷 / 04期

关键词：

mesothelioma; asbestos; gender; PLEURAL MESOTHELIOMA; PERITONEAL MESOTHELIOMA; ENVIRONMENTAL EXPOSURE; REGISTER; WORKERS; TRENDS; COMPENSATION; DETERMINANTS; SURVEILLANCE; AUSTRALIA;

D O I：

10.1136/oemed-2016-104119

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Introduction The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. Methods Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated. Results In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries. Conclusions The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.

引用

页码：254 / 262

页数：9

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