Cutting DNA: Mechanics of the topoisomerase

被引：3

作者：

Thompson, J. M. T. ^{[1
,2
]}

机构：

[1] Univ Aberdeen, Sch Engn, Aberdeen AB9 1FX, Scotland

[2] Ctr Math Sci, Dept Appl Math & Theoret Phys, Cambridge, MA USA

来源：

EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS | 2008年 / 165卷 / 1期

关键词：

D O I：

10.1140/epjst/e2008-00861-1

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Taking the accurate theoretical solutions of Coleman and Swigon for a DNA plasmid in a plectonemic state under imposed link and responsive writhe, we examine in detail the working of the two types of cutting enzyme (topoisomerase Type 1 and topoisomerase Type 2). The mechanical processes involved can generate a plethora of outcomes, all assigning different levels of relaxation to the molecule. Alternative outcomes arise when there are co-existing (meta-)stable equilibrium states. Resolution of the outcome would then require a dynamic analysis of the relaxation process, though the Maxwell criterion can offer some guidance.

引用

页码：175 / 182

页数：8

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