Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?

被引:30
作者
Chiorescu, Roxana Mihaela [1 ,2 ]
Mocan, Mihaela [1 ,2 ]
Inceu, Andreea Ioana [3 ,4 ]
Buda, Andreea Paula [4 ]
Blendea, Dan [5 ]
Vlaicu, Sonia Irina [1 ,2 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Internal Med Dept, Cluj Napoca 400012, Romania
[2] Emergency Clin Cty Hosp, Dept Internal Med, Cluj Napoca 400006, Romania
[3] Iuliu Hatieganu Univ Med, Dept Pharmacol Toxicol & Clin Pharmacol, Cluj Napoca 400349, Romania
[4] Nicolae Stancioiu Heart Inst, Dept Cardiol, Cluj Napoca 400001, Romania
[5] Iuliu Hatieganu Univ Med & Pharm, Dept Cardiol, Cluj Napoca 400437, Romania
关键词
atherosclerosis; vulnerable plaque; inflammatory biomarkers; proteomics; micro-RNAs; oxidative stress; ACUTE CORONARY SYNDROMES; ACUTE MYOCARDIAL-INFARCTION; PLASMA PROTEIN-A; CARDIOVASCULAR EVENTS; ENDOTHELIAL DYSFUNCTION; NLRP3; INFLAMMASOME; PROGNOSTIC VALUE; ARTERY; RISK; ACTIVATION;
D O I
10.3390/ijms232113638
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are the most common cause of death worldwide. The main pathophysiological mechanism for these complications is the rupture of vulnerable atherosclerotic plaques and subsequent thrombosis. Pathological studies of the vulnerable lesions showed that more frequently, plaques rich in lipids and with a high level of inflammation, responsible for mild or moderate stenosis, are more prone to rupture, leading to acute events. Identifying the vulnerable plaques helps to stratify patients at risk of developing acute vascular events. Traditional imaging methods based on plaque appearance and size are not reliable in prediction the risk of rupture. Intravascular imaging is a novel technique able to identify vulnerable lesions, but it is invasive and an operator-dependent technique. This review aims to summarize the current data from literature regarding the main biomarkers involved in the attempt to diagnose vulnerable atherosclerotic lesions. These biomarkers could be the base for risk stratification and development of the new therapeutic drugs in the treatment of patients with vulnerable atherosclerotic plaques.
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页数:36
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