Celastrol as a tool for the study of the biological events of metabolic diseases

被引：12
作者：
Lan, Gongcai [1 ,2 ]
Zhang, Jie [2 ]
Ye, Wenbo [3 ]
Yang, Fan [2 ,4 ]
Li, Ang [3 ,5 ]
He, Weiwei [2 ,5 ]
Zhang, Wei-Dong [1 ,2 ,4 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China
[2] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
[4] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China
[5] Jiangxi Qingfeng Pharmaceut Co Ltd, State Key Lab Innovat Nat Med & Tradit Chinese Me, Ganzhou 341000, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2019年 / 62卷 / 04期
基金：
中国国家自然科学基金;
关键词：
celastrol; obesity; type; 2; diabetes; endoplasmic reticulum stress; inflammation; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; LEPTIN RECEPTOR; MITOCHONDRIAL BIOGENESIS; SIGNAL TRANSDUCER; HSP90; INHIBITOR; OBESITY; INFLAMMATION; COMPLEX;
D O I：
10.1007/s11426-018-9404-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chinese medicine for treating rheumatoid arthritis. Previous studies showed that celastrol possessed diverse biological activities, including anti-inflammatory and anticancer properties. Interestingly, most recent literatures revealed the important role of celastrol against metabolic disorders. Herein, we provide an overview of the modes of action of celastrol for combating metabolic diseases such as obesity and type 2 diabetes. The anti-obesity effect of celastrol results from relieving endoplasmic reticulum stress in hypothalamus, regulating HSF1-PGC1 alpha axis in the adipose tissue and muscle, and alleviating inflammation via Nur77 mediated autophagy. Celastrol also reverses insulin resistance via NF-kappa B signaling pathway to protect against type 2 diabetes.
引用
收藏
页码：409 / 416
页数：8
相关论文
共 76 条
[41]   Mitochondria and endocrine function of adipose tissue [J].
Medina-Gomez, Gema .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 26 (06) :791-804
[42]   Methods in Mammalian Autophagy Research [J].
Mizushima, Noboru ;
Yoshimori, Tamotsu ;
Levine, Beth .
CELL, 2010, 140 (03) :313-326
[43]   The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease [J].
Morimoto, Richard I. .
METABOLISM AND DISEASE, 2011, 76 :91-99
[44]   Central nervous system control of food intake and body weight [J].
Morton, G. J. ;
Cummings, D. E. ;
Baskin, D. G. ;
Barsh, G. S. ;
Schwartz, M. W. .
NATURE, 2006, 443 (7109) :289-295
[45]   Molecular and anatomical determinants of central leptin resistance [J].
Münzberg, H ;
Myers, MG .
NATURE NEUROSCIENCE, 2005, 8 (05) :566-570
[46]   Obesity and leptin resistance: distinguishing cause from effect [J].
Myers, Martin G., Jr. ;
Leibel, Rudolph L. ;
Seeley, Randy J. ;
Schwartz, Michael W. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (11) :643-651
[47]   STRUCTURE OF PRISTIMERIN AND CELASTROL [J].
NAKANISHI, K ;
KAKISAWA, H ;
HIRATA, Y .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (11) :3169-3171
[48]   NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis [J].
Ni, Haiwen ;
Zhao, Wanzhou ;
Kong, Xiangtu ;
Li, Haitao ;
Ouyang, Jian .
PLOS ONE, 2014, 9 (04)
[49]   Mitochondria: In Sickness and in Health [J].
Nunnari, Jodi ;
Suomalainen, Anu .
CELL, 2012, 148 (06) :1145-1159
[50]   Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes [J].
Oezcan, Umut ;
Yilmaz, Erkan ;
Oezcan, Lale ;
Furuhashi, Masato ;
Vaillancourt, Eric ;
Smith, Ross O. ;
Goerguen, Cem Z. ;
Hotamisligil, Goekhan S. .
SCIENCE, 2006, 313 (5790) :1137-1140
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