Regulatory cytokine function in the respiratory tract

被引：98

作者：

Branchett, William J. ^{[1
,2
]}

Lloyd, Clare M. ^{[1
,2
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, London, England

[2] Imperial Coll London, Asthma UK Ctr Allerg Mech Asthma, London, England

来源：

MUCOSAL IMMUNOLOGY | 2019年 / 12卷 / 03期

基金：

英国惠康基金;

关键词：

GROWTH-FACTOR-BETA; T-HELPER-CELLS; INDUCED AIRWAY HYPERREACTIVITY; INFLUENZA-VIRUS INFECTION; NECROSIS-FACTOR-ALPHA; TGF-BETA; INTERLEUKIN-10; RECEPTOR; ALVEOLAR MACROPHAGES; IMMUNE-RESPONSES; IL-10; PRODUCTION;

D O I：

10.1038/s41385-019-0158-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor beta, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Here, we discuss the role of these cytokines during respiratory infection and allergic airway disease, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.

引用

页码：589 / 600

页数：12

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