The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

被引：173
|
作者：
Moens, Ugo [1 ]
Kostenko, Sergiy [1 ]
Sveinbjornsson, Baldur [1 ]
机构：
[1] Univ Tromso, Fac Hlth Sci, Dept Med Biol, Mol Inflammat Res Grp, NO-9037 Tromso, Norway
来源：
GENES | 2013年 / 4卷 / 02期
关键词：
RSK; MSK; MNK; MK2; MK3; MK5; NF-kappa B; STAT3; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; VASCULAR SMOOTH-MUSCLE; CYTOSOLIC PHOSPHOLIPASE A(2); MESSENGER-RNA STABILITY; AU-RICH ELEMENT; TNF-ALPHA; GENE-EXPRESSION; ANGIOTENSIN-II; NUCLEAR-FACTOR;
D O I：
10.3390/genes4020101
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and convert a plethora of extracellular signals by three consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK kinase, and a MAPK. In turn MAPKs phosphorylate substrates, including other protein kinases referred to as MAPK-activated protein kinases (MAPKAPKs). Eleven mammalian MAPKAPKs have been identified: ribosomal-S6-kinases (RSK1-4), mitogen-and stress-activated kinases (MSK1-2), MAPK-interacting kinases (MNK1-2), MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and MAPKAPK-5 (MK5). The role of these MAPKAPKs in inflammation will be reviewed.
引用
收藏
页码：101 / 133
页数：33
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