Celastrol-based nanomedicine hydrogels eliminate posterior capsule opacification

被引：9

作者：

Zhang, Ying ^{[1
]}

Liu, Ruixing ^{[1
]}

Li, Chengcheng ^{[1
]}

Shi, Liuqi ^{[1
]}

Guo, Zhihua ^{[1
]}

Zhu, Lei ^{[1
]}

Li, Wen ^{[2
]}

Li, Jingguo ^{[1
]}

Li, Zhanrong ^{[1
]}

机构：

[1] Zhengzhou Univ, Peoples Hosp, Henan Eye Hosp, Henan Prov Peoples Hosp, Zhengzhou 450003, Peoples R China

[2] Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200444, Peoples R China

来源：

NANOMEDICINE | 2022年 / 17卷 / 20期

基金：

中国国家自然科学基金;

关键词：

celastrol; epithelial-mesenchymal transition; hydrogel; nanomedicine; posterior capsule opacification; EPITHELIAL-MESENCHYMAL TRANSITION; CORNEAL NEOVASCULARIZATION; INTRAOCULAR-LENS; CELLS; MIGRATION; PROLIFERATION; NANOPARTICLES; DELIVERY;

D O I：

10.2217/nnm-2022-0191

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To formulate an injectable thermosensitive micelle-hydrogel hybrid system loaded with celastrol (celastrol-loaded micelle hydrogel: CMG) to prevent posterior capsule opacification (PCO). Materials & methods: Celastrol-loaded micelles were embedded in a thermosensitive hydrogel matrix to enable controlled on-demand celastrol delivery into the residual capsule. The efficacy and mechanisms of the system for eliminating PCO were evaluated in rabbits. Results: Celastrol-loaded micelles inhibited the migration and proliferation of lens epithelial cells induced by TGF-beta 1. Celastrol prevents epithelial-mesenchymal transition in lens epithelial cells induced by TGF-beta 1 through the TGF-beta 1/Smad2/3/TEAD1 signaling pathway. In vivo efficiency evaluations showed that CMG demonstrated an excellent inhibitory effect on PCO in rabbits and had no obvious tissue toxicity. Conclusion: Injectable CMG may represent a promising ophthalmic platform for preventing PCO. This versatile injectable micelle-hydrogel hybrid represents a clinically relevant platform to achieve localized therapy and controlled release of drugs in other disease therapies.

引用

页码：1449 / 1461

页数：13

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