The role of Toll-like receptors in viral infections - selected data

被引：2

作者：

Niedzwiedzka-Rystwej, Paulina ^{[1
]}

Tokarz-Deptula, Beata ^{[1
]}

Deptula, Wieslaw ^{[2
]}

机构：

[1] Univ Szczecin, Dept Immunol, Fac Biol, PL-71412 Szczecin, Poland

[2] Univ Szczecin, Dept Microbiol, Fac Biol, PL-71412 Szczecin, Poland

来源：

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY | 2013年 / 38卷 / 01期

关键词：

Toll-like receptors; viral recognition; rabbit haemorrhagic disease; PATTERN-RECOGNITION RECEPTORS; HEMORRHAGIC-DISEASE VIRUS; INNATE IMMUNE-RESPONSE; MECHANISMS; EVOLUTION; HEALTH;

D O I：

10.5114/ceji.2013.34368

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are very well known for their antibacterial, antiviral and antiparasite importance. Nowadays, there are 18 TLRs - TLR 1-13 in human, and TLR14, 15, 21, 22, 23 among others vertebrates and invertebrates. As pivotal pathogen recognition receptors (PRR) they tend to be a part of many infections. Their role in bacterial infection is unquestioned, nevertheless, this paper shows the importance of those receptors in viral infections. Virus recognition by TLRs is based on the characteristics of PAMP - dsRNA, CpG motif of viral DNA, ssRNA and viral glycoprotein envelopes. Moreover, the role of TLRs in viral haemorrhagic disease in rabbits as an interesting matter for authors, has been described.

引用

页码：118 / 121

页数：4

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