Synthesis and Evaluation of Some Novel 2-Amino-4-Aryl Thiazoles for Antitubercular Activity

被引：14

作者：

Gundlewad, Gangadhar B. ^{[1
]}

Patil, Bhagwan R. ^{[2
]}

机构：

[1] Shri Shivaji Coll, Dept Chem, Parbhani 431401, Maharashtra, India

[2] Sharda Mahavidyalaya, Dept Chem, Parbhani 431401, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 03期

关键词：

EFFICIENT SYNTHESIS; RECEPTOR LIGANDS; DERIVATIVES; AGENTS; INHIBITORS;

D O I：

10.1002/jhet.3098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2-amino-4-aryl thiazoles were synthesized from -chloroacetophenone and thiourea at room temperature using acetone as solvent. The structures of synthesized compounds were confirmed by spectral data. All the compounds were evaluated for antitubercular activity by macro broth dilution method against Mycobacterium Tuberculosis H37Rv as standard strain. The synthesized compound displays notable antitubercular activity.

引用

页码：769 / 774

页数：6

共 50 条

[1] Synthesis and evaluation of in vitro antitubercular activity and antimicrobial activity of some novel 4H-chromeno[2,3-d]pyrimidine via 2-amino-4-phenyl-4H-chromene-3-carbonitriles
Kamdar, Nimesh R.
Haveliwala, Dhaval D.
Mistry, Prashant T.
Patel, Saurabh K.
MEDICINAL CHEMISTRY RESEARCH, 2011, 20 (07) : 854 - 864
[2] An efficient synthesis of novel 2-amino-4-aryl-6-ferrocenyl pyrimidines
Rashinkar, G. S.
Pore, S. B.
Mote, K. B.
Salunkhe, R. S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (04): : 606 - 610
[3] Synthesis and Antibacterial Activity of 4-Aryl-2-(1-substituted ethylidene)thiazoles
Hassan, Alaa A.
Ibrahim, Yusria R.
El-Sheref, Essmat M.
Abdel-Aziz, Mohamed
Braese, Stefan
Nieger, Martin
ARCHIV DER PHARMAZIE, 2013, 346 (07) : 562 - 570
[4] 2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor
Sinha, Shweta
Sravanthi, T. V.
Yuvaraj, S.
Manju, S. L.
Doble, Mukesh
RSC ADVANCES, 2016, 6 (23): : 19271 - 19279
[5] Synthesis, docking, and evaluation of novel thiazoles for potent antidiabetic activity
Sravanthi, T. V.
Lulu, S. Sajitha
Vino, S.
Jayasri, M. A.
Mohanapriya, A.
Manju, S. L.
MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (06) : 1306 - 1315
[6] One-pot sustainable synthesis of novel pyrido[2,3-d]pyrimidinones and their evaluation for antitubercular and anticancer activity
Tabassum, Sumaiya
Ramaraj, Sankar Ganesh
Rajprasad, J.
Sadaiyandi, Vivekananthan
Kumar, Niraj
Govindaraju, Santhosh
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2025, 1025
[7] Synthesis and characterization of some novel bis-thiazoles
Mahmoud, Huda K.
Kassab, Refaie M.
Gomha, Sobhi M.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (11) : 3157 - 3163
[8] Design, synthesis, anticancer activity and mechanism studies of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid
Wang, Wen-Yan
Yang, Zi-Hui
Li, A-Liang
Liu, Qing-Song
Sun, Yue
Gu, Wen
NEW JOURNAL OF CHEMISTRY, 2022, 46 (05) : 2335 - 2350
[9] Synthesis and Anticancer Evaluation of Some Novel 5-Amino[1,2,4]Triazole Derivatives
Hassan, Aisha Y.
Sarg, Marwa T.
Bayoumi, Ashraf H.
El-Deeb, Moshira A.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (06) : 1450 - 1478
[10] Synthesis, Antitubercular Activity, and Molecular Docking Studies of Novel 2-(4-Chlorobenzylamino)-4-(cyclohexylmethylamino)-pyrimidine-5-carboxamides
Srinu, B.
Parameshwar, R.
Charan, G. Kali
Srinivas, E.
Rao, Ch. P. Koteswara
Chandra, J. N. Narendra Sharath
Varma, S. Naresh
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (04) : 836 - 843

← 1 2 3 4 5 →