Synthesis and Evaluation of Some Novel 2-Amino-4-Aryl Thiazoles for Antitubercular Activity

被引：15

作者：

Gundlewad, Gangadhar B. ^{[1
]}

Patil, Bhagwan R. ^{[2
]}

机构：

[1] Shri Shivaji Coll, Dept Chem, Parbhani 431401, Maharashtra, India

[2] Sharda Mahavidyalaya, Dept Chem, Parbhani 431401, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 03期

关键词：

EFFICIENT SYNTHESIS; RECEPTOR LIGANDS; DERIVATIVES; AGENTS; INHIBITORS;

D O I：

10.1002/jhet.3098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2-amino-4-aryl thiazoles were synthesized from -chloroacetophenone and thiourea at room temperature using acetone as solvent. The structures of synthesized compounds were confirmed by spectral data. All the compounds were evaluated for antitubercular activity by macro broth dilution method against Mycobacterium Tuberculosis H37Rv as standard strain. The synthesized compound displays notable antitubercular activity.

引用

页码：769 / 774

页数：6

共 24 条

[1] Synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones [J].

Aridoss, G. ;

Amirthaganesan, S. ;

Kim, M. S. ;

Kim, J. T. ;

Jeong, Yeon Tae .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) :4199-4210

[2] Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors [J].

Carter, JS ;

Kramer, S ;

Talley, JJ ;

Penning, T ;

Collins, P ;

Graneto, MJ ;

Seibert, K ;

Koboldt, CM ;

Masferrer, J ;

Zweifel, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (08) :1171-1174

[3] Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. [J].

Chimenti, Franco ;

Bizzarri, Bruna ;

Maccioni, Elias ;

Secci, Daniela ;

Bolasco, Adriana ;

Fioravanti, Rossella ;

Chimenti, Paola ;

Granese, Arianna ;

Carradori, Simone ;

Rivanera, Daniela ;

Lilli, Daniela ;

Zicari, Alessandra ;

Distinto, Simona .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (16) :4635-4640

[4] A novel entry toward 2-imino-1,3-thiazolidines and 2-imino-1,3-thiazolines by ring transformation of 2-(thiocyanomethyl)aziridines [J].

D'hooghe, M ;

Waterinckx, A ;

De Kimpe, N .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (01) :227-232

[5]

Dhumal S. T., 2017, J HETEROCYCLIC CHEM

[6]

Dighe S. N., 2011, ISRN ORGANIC CHEM

[7] Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens [J].

Fink, BE ;

Mortensen, DS ;

Stauffer, SR ;

Aron, ZD ;

Katzenellenbogen, JA .

CHEMISTRY & BIOLOGY, 1999, 6 (04) :205-219

[8]

Hantzsch A., 1887, BERICHTE DTSCH CHEM, V20, P3118, DOI [10.1002/cber.188702002200, DOI 10.1002/CBER.188702002200]

[9] An efficient synthesis of thiazol-2-imine derivatives via a one-pot, three-component reaction [J].

Heravi, Majid M. ;

Moghimi, Setareh .

TETRAHEDRON LETTERS, 2012, 53 (04) :392-394

[10]

Hoshino K, 2002, Drug Discharging Pump Inhibitor Japan Patent, Patent No. [2002322054, JP 2002322054 A]

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