Neutrophil mechanotransduction: A GEF to sense fluid shear stress

被引：5

作者：

Niethammer, Philipp ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 01期

关键词：

INFLAMMATION; MIGRATION;

D O I：

10.1083/jcb.201609101

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEFH1 as critical for shear stress induced transendothelial neutrophil migration.

引用

页码：13 / 14

页数：2

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