Tandem Radical Cyclization for the Construction of Difluoro-Containing Oxindoles and Quinoline-2,4-diones

被引:27
作者
Ding, Fangwei [1 ,2 ]
Fang, Yuanding [2 ]
Jiang, Yanqiu [1 ]
Lin, Kaifeng [1 ]
Shi, Lei [1 ,2 ]
机构
[1] Harbin Inst Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China
[2] Harbin Inst Technol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
关键词
cyclization; difluoromethylation; oxindoles; quinolines; radical reactions; LIGHT PHOTOREDOX CATALYSIS; COPPER-MEDIATED DIFLUOROMETHYLATION; C-H DIFLUOROACETYLATION; ACTIVATED ALKENES; ADDITION/CYCLIZATION CASCADE; N-ARYLACRYLAMIDES; CARBOXYLIC-ACIDS; ACCESS; ARYL; QUINOLINE-2,4(1H,3H)-DIONES;
D O I
10.1002/asia.201701780
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Cu-catalyzed direct difluoromethylation of activated alkenes through a difluoromethyl radical addition/cyclization to afford difluorinated oxindoles and quinoline-2,4-diones has been developed. This method provides convenient access to a variety of oxindoles and quinoline-2,4-diones under mild conditions via a proposed tandem radical cyclization process, while tolerating various functional groups well. Moreover, a facile method to construct diverse difluorinated quinoline-2,4-diones by visible-light photoredox catalysis under mild conditions was presented.
引用
收藏
页码:636 / 640
页数:5
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