Tandem Radical Cyclization for the Construction of Difluoro-Containing Oxindoles and Quinoline-2,4-diones

被引：27

作者：

Ding, Fangwei ^{[1
,2
]}

Fang, Yuanding ^{[2
]}

Jiang, Yanqiu ^{[1
]}

Lin, Kaifeng ^{[1
]}

Shi, Lei ^{[1
,2
]}

机构：

[1] Harbin Inst Technol, MIIT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China

[2] Harbin Inst Technol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 06期

关键词：

cyclization; difluoromethylation; oxindoles; quinolines; radical reactions; LIGHT PHOTOREDOX CATALYSIS; COPPER-MEDIATED DIFLUOROMETHYLATION; C-H DIFLUOROACETYLATION; ACTIVATED ALKENES; ADDITION/CYCLIZATION CASCADE; N-ARYLACRYLAMIDES; CARBOXYLIC-ACIDS; ACCESS; ARYL; QUINOLINE-2,4(1H,3H)-DIONES;

D O I：

10.1002/asia.201701780

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cu-catalyzed direct difluoromethylation of activated alkenes through a difluoromethyl radical addition/cyclization to afford difluorinated oxindoles and quinoline-2,4-diones has been developed. This method provides convenient access to a variety of oxindoles and quinoline-2,4-diones under mild conditions via a proposed tandem radical cyclization process, while tolerating various functional groups well. Moreover, a facile method to construct diverse difluorinated quinoline-2,4-diones by visible-light photoredox catalysis under mild conditions was presented.

引用

页码：636 / 640

页数：5

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