The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134

被引：106
作者：
Bicker, Silvia [1 ]
Khudayberdiev, Sharof [1 ]
Weiss, Kerstin [1 ]
Zocher, Kathleen [1 ]
Baumeister, Stefan [2 ]
Schratt, Gerhard [1 ]
机构：
[1] Univ Marburg, Inst Physiol Chem, Biochem Pharmakol Ctr Marburg, D-35032 Marburg, Germany
[2] Univ Marburg, Fachbereich Biol Prot Analyt, D-35032 Marburg, Germany
来源：
GENES & DEVELOPMENT | 2013年 / 27卷 / 09期
关键词：
dendritic transport; DHX36; precursor-microRNA; protein synthesis; synaptic plasticity; MESSENGER-RNA; MICRORNA BIOGENESIS; MOUSE-BRAIN; TRANSLATION; DENDRITOGENESIS; PLASTICITY; TRANSPORT; REVEALS; PATHWAY; MEMORY;
D O I：
10.1101/gad.211243.112
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SpecificmicroRNAs (miRNAs), includingmiR-134, localize to neuronal dendrites, where they control synaptic protein synthesis and plasticity. However, the mechanism of miRNA transport is unknown. We found that the neuronal precursor-miRNA-134 (pre-miR-134) accumulates in dendrites of hippocampal neurons and at synapses in vivo. Dendritic localization of pre-miR-134 is mediated by the DEAH-box helicase DHX36, which directly associates with the pre-miR-134 terminal loop. DHX36 function is required for miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Dendritically localized pre-miR-134 could provide a local source of miR-134 that can be mobilized in an activity-dependent manner during plasticity.
引用
收藏
页码：991 / 996
页数：6
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