βCTF-Correlated Burst of Hippocampal TNFα Occurs at a Very Early, Pre-Plaque Stage in the TgCRND8 Mouse Model of Alzheimer's Disease

被引:33
作者
Cavanagh, Chelsea [1 ]
Colby-Milley, Jessica [1 ]
Bouvier, David [1 ]
Farso, Mark [1 ]
Chabot, Jean-Guy [1 ]
Quirion, Remi [1 ]
Krantic, Slavica [1 ]
机构
[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
关键词
Alzheimer's disease; beta-C-terminal fragment; pre-plaque; TgCRND8; mice; tumor necrosis factor-alpha; AMYLOID DEPOSITION; MICROGLIAL CELLS; INTERFERON-GAMMA; PROTEIN;
D O I
10.3233/JAD-122131
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tumor necrosis factor-alpha (TNF alpha) regulates neuronal excitability. We investigated whether alterations in the level of TNF alpha occur at a time point that precedes the reported seizure-associated hyperexcitability of hippocampal networks in pre-plaque models of Alzheimer's disease (AD). Western blot and ELISA experiments indicated a significant increase in hippocampal TNF alpha expression in 1-month-old TgCRND8 mice that correlated with levels of the beta-C-terminal fragment (beta CTF) of amyloid-beta protein precursor. CD11b labeling indicated changes in microglial morphology toward an activated state, suggesting that these cells may be a putative source of the observed TNF alpha increase during this pre-symptomatic stage of AD-like pathology.
引用
收藏
页码:233 / 238
页数:6
相关论文
共 25 条
[1]   Early molecular and synaptic dysfunctions in the prodromal stages of Alzheimer's disease: focus on TNF-alpha and IL-1 beta [J].
Cavanagh, Chelsea ;
Colby-Milley, Jessica ;
Farso, Mark ;
Krantic, Slavica ;
Quirion, Remi .
FUTURE NEUROLOGY, 2011, 6 (06) :757-769
[2]   Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695 [J].
Chishti, MA ;
Yang, DS ;
Janus, C ;
Phinney, AL ;
Horne, P ;
Pearson, J ;
Strome, R ;
Zuker, N ;
Loukides, J ;
French, J ;
Turner, S ;
Lozza, G ;
Grilli, M ;
Kunicki, S ;
Morissette, C ;
Paquette, J ;
Gervais, F ;
Bergeron, C ;
Fraser, PE ;
Carlson, GA ;
St George-Hyslop, P ;
Westaway, D .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (24) :21562-21570
[3]   An Overview of APP Processing Enzymes and Products [J].
Chow, Vivian W. ;
Mattson, Mark P. ;
Wong, Philip C. ;
Gleichmann, Marc .
NEUROMOLECULAR MEDICINE, 2010, 12 (01) :1-12
[4]   Increased seizure threshold and severity in young transgenic CRND8 mice [J].
Del Vecchio, RA ;
Gold, LH ;
Novick, SJ ;
Wong, G ;
Hyde, LA .
NEUROSCIENCE LETTERS, 2004, 367 (02) :164-167
[5]   Inflammation occurs early during the Aβ deposition process in TgCRND8 mice [J].
Dudal, S ;
Krzywkowski, P ;
Paquette, J ;
Morissette, C ;
Lacombe, D ;
Tremblay, P ;
Gervais, F .
NEUROBIOLOGY OF AGING, 2004, 25 (07) :861-871
[6]   Object recognition memory and BDNF expression are reduced in young TgCRND8 mice [J].
Francis, Beverly M. ;
Kim, John ;
Barakat, Meredith E. ;
Fraenkl, Stephan ;
Yuecel, Yeni H. ;
Peng, Shiyong ;
Michalski, Bernadeta ;
Fahnestock, Margaret ;
McLaurin, JoAnne ;
Mount, Howard T. J. .
NEUROBIOLOGY OF AGING, 2012, 33 (03) :555-563
[7]   Microglia: active sensor and versatile effector cells in the normal and pathologic brain [J].
Hanisch, Uwe-Karsten ;
Kettenmann, Helmut .
NATURE NEUROSCIENCE, 2007, 10 (11) :1387-1394
[8]   AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].
HARDY, J ;
ALLSOP, D .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388
[9]   SEIZURES AND MYOCLONUS IN PATIENTS WITH ALZHEIMERS-DISEASE [J].
HAUSER, WA ;
MORRIS, ML ;
HESTON, LL ;
ANDERSON, VE .
NEUROLOGY, 1986, 36 (09) :1226-1230
[10]   Quantitating the subtleties of microglial morphology with fractal analysis [J].
Karperien, Audrey ;
Ahammer, Helmut ;
Jelinek, Herbert F. .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7 :1-34