α-synuclein and cytosolic dopamine:: Stabilizing a bad situation

被引：48

作者：

Sulzer, D ^{[1
]}

机构：

[1] Columbia Univ, Dept Neurol, New York, NY 10027 USA

[2] Columbia Univ, Dept Psychiat, New York, NY USA

[3] New York State Psychiat Inst & Hosp, Dept Neurosci, New York, NY 10032 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 12期

关键词：

D O I：

10.1038/nm1201-1280

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intriguing finding that alpha -synuclein-a protein recently found to be mutated in some familial cases of Parkinson disease-and cytosolic dopamine interact to form adducts that stabilize a presumably toxic intermediate of fibril formation provides clues into the mechanism of neurodegeneration.

引用

收藏

页码：1280 / 1282

页数：3

相关论文

共 11 条

[1] Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system [J].

Abeliovich, A ;

Schmitz, Y ;

Fariñas, I ;

Choi-Lundberg, D ;

Ho, WH ;

Castillo, PE ;

Shinsky, N ;

Verdugo, JMG ;

Armanini, M ;

Ryan, A ;

Hynes, M ;

Phillips, H ;

Sulzer, D ;

Rosenthal, A .

NEURON, 2000, 25 (01) :239-252

[2] The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease [J].

Clayton, DF ;

George, JM .

TRENDS IN NEUROSCIENCES, 1998, 21 (06) :249-254

[3] Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease:: Implications for pathogenesis and therapy [J].

Conway, KA ;

Lee, SJ ;

Rochet, JC ;

Ding, TT ;

Williamson, RE ;

Lansbury, PT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :571-576

[4] Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct [J].

Conway, KA ;

Rochet, JC ;

Bieganski, RM ;

Lansbury, PT .

SCIENCE, 2001, 294 (5545) :1346-1349

[5] METHAMPHETAMINE NEUROTOXICITY INVOLVES VACUOLATION OF ENDOCYTIC ORGANELLES AND DOPAMINE-DEPENDENT INTRACELLULAR OXIDATIVE STRESS [J].

CUBELLS, JF ;

RAYPORT, S ;

RAJENDRAN, G ;

SULZER, D .

JOURNAL OF NEUROSCIENCE, 1994, 14 (04) :2260-2271

[6] β-synuclein inhibits α-synuclein aggregation:: A possible role as an anti-parkinsonian factor [J].

Hashimoto, M ;

Rockenstein, E ;

Mante, M ;

Mallory, M ;

Masliah, E .

NEURON, 2001, 32 (02) :213-223

[7] Synucleins are developmentally expressed, and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons [J].

Murphy, DD ;

Rueter, SM ;

Trojanowski, JQ ;

Lee, VMY .

JOURNAL OF NEUROSCIENCE, 2000, 20 (09) :3214-3220

[8] Mutation in the alpha-synuclein gene identified in families with Parkinson's disease [J].

Polymeropoulos, MH ;

Lavedan, C ;

Leroy, E ;

Ide, SE ;

Dehejia, A ;

Dutra, A ;

Pike, B ;

Root, H ;

Rubenstein, J ;

Boyer, R ;

Stenroos, ES ;

Chandrasekharappa, S ;

Athanassiadou, A ;

Papapetropoulos, T ;

Johnson, WG ;

Lazzarini, AM ;

Duvoisin, RC ;

DiIorio, G ;

Golbe, LI ;

Nussbaum, RL .

SCIENCE, 1997, 276 (5321) :2045-2047

[9] Ubiquitination of a new form of α-synuclein by parkin from human brain:: Implications for Parkinson's disease [J].

Shimura, H ;

Schlossmacher, MC ;

Hattori, N ;

Frosch, MP ;

Trockenbacher, A ;

Schneider, R ;

Mizuno, Y ;

Kosik, KS ;

Selkoe, DJ .

SCIENCE, 2001, 293 (5528) :263-269

[10] alpha-synuclein in Lewy bodies [J].

Spillantini, MG ;

Schmidt, ML ;

Lee, VMY ;

Trojanowski, JQ ;

Jakes, R ;

Goedert, M .

NATURE, 1997, 388 (6645) :839-840