Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

被引：142

作者：

Harden, Jamie L. ^{[1
]}

Egilmez, Nejat K. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Microbiol & Immunol, Buffalo, NY 14214 USA

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2012年 / 41卷 / 6-7期

关键词：

Dendritic Cells; Indoleamine 2,3-dioxygenase; Immune tolerance; ARYL-HYDROCARBON RECEPTOR; REGULATORY T-CELLS; TRYPTOPHAN CATABOLISM; CUTTING EDGE; IFN-GAMMA; EFFECTOR/MEMORY CELLS; IMMUNE SUPPRESSION; SKIN DELIVERY; IDO; INHIBITION;

D O I：

10.3109/08820139.2012.676122

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maintenance of IDO-expression in response to inflammatory stimuli and how selective modulation of IDO activity may be used in the treatment of disease.

引用

页码：738 / 764

页数：27

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