CHOgenome.org 2.0: Genome resources and website updates

被引：26
作者：
Kremkow, Benjamin G. [1 ,2 ]
Baik, Jong Youn [1 ,2 ]
MacDonald, Madolyn L. [2 ,3 ]
Lee, Kelvin H. [1 ,2 ]
机构：
[1] Univ Delaware, Chem & Biomol Engn, Newark, DE 19716 USA
[2] Delaware Biotechnol Inst, Newark, DE 19711 USA
[3] Univ Delaware, Comp & Informat Sci, Newark, DE USA
来源：
BIOTECHNOLOGY JOURNAL | 2015年 / 10卷 / 07期
基金：
美国国家科学基金会;
关键词：
Bioinformatics; Biomanufacturing; CHO cell; Genomics; Systems biology; RECOMBINANT PROTEIN THERAPEUTICS; CHO-CELLS; HAMSTER; SEQUENCE; DATABASE; FORMAT; BIOTECHNOLOGY; REVOLUTION; STATE; LINES;
D O I：
10.1002/biot.201400646
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Chinese hamster ovary (CHO) cells are a major host cell line for the production of therapeutic proteins, and CHO cell and Chinese hamster (CH) genomes have recently been sequenced using next-generation sequencing methods. CHOgenome.org was launched in 2011 (version 1.0) to serve as a database repository and to provide bioinformatics tools for the CHO community. CHOgenome.org (version 1.0) maintained GenBank CHO-K1 genome data, identified CHO-omics literature, and provided a CHO-specific BLAST service. Recent major updates to CHOgenome.org (version 2.0) include new sequence and annotation databases for both CHO and CH genomes, a more user-friendly website, and new research tools, including a proteome browser and a genome viewer. CHO cell-line specific sequences and annotations facilitate cell line development opportunities, several of which are discussed. Moving forward, CHOgenome.org will host the increasing amount of CHO-omics data and continue to make useful bioinformatics tools available to the CHO community.
引用
收藏
页码：931 / 938
页数：8
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