PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer

被引：16
作者：
Gonzalez-Alonso, Paula [1 ]
Cristobal, Ion [2 ]
Manso, Rebeca [1 ]
Madoz-Gurpide, Juan [1 ]
Garcia-Foncillas, Jesus [2 ]
Rojo, Federico [1 ]
机构：
[1] IIS Fdn Jimenez Diaz, Dept Pathol, Madrid 28040, Spain
[2] Univ Hosp Fdn Jimenez Diaz, Oncohlth Inst, Translat Oncol Div, IIS Fdn Jimenez Diaz,UAM, Madrid 28040, Spain
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 08期
关键词：
PP2A; FTY720; Cabazitaxel; Castration-resistant prostate cancer; PROTEIN PHOSPHATASE 2A; CELLS; ACTIVATION; EXPRESSION; STRATEGY; PATHWAY;
D O I：
10.1007/s13277-015-3849-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Protein phosphatase 2A (PP2A) is a well-known tumor suppressor frequently inhibited in human cancer. Alterations affecting PP2A subunits together with the deregulation of endogenous PP2A inhibitors such as CIP2A and SET have been described as contributing mechanisms to inactivate PP2A in prostate cancer. Moreover, recent findings highlight that functional inactivation of PP2A could represent a key event in the acquisition of castration-resistant phenotype and a novel molecular target with high impact at both clinical and therapeutic levels in prostate cancer.
引用
收藏
页码：5753 / 5755
页数：3
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