1H and 13C NMR spectra of condensed benzimidazole and imidazobenzodiazepines

被引：3
作者：
El Kihel, A. [1 ]
Essassi, E. M. [2 ]
Bauchat, P. [3 ]
机构：
[1] Fac Sci, Chim Bioorgan Lab, El Jadida 24000, Maroc, Morocco
[2] Fac Sci Rabat, Lab Chim Organ Heterocycl, Rabat 10000, Maroc, Morocco
[3] Univ Rennes1, Lab Synth & Electrosynth Organ, F-35042 Rennes, France
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2012年 / 5卷 / 04期
关键词：
Benzimidazole; Imidazobenzodiazepines; H-1 and C-13 NMR; H-1-C-13; correlation; NUCLEAR-MAGNETIC-RESONANCE; TRANSMISSION; DERIVATIVES; RAMAN;
D O I：
10.1016/j.arabjc.2010.09.021
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Benzimidazoles are heterocyclic compounds that have awakened great interest during the last few years because of their proven biological activity as antiviral, antimicrobial, and antitumoral agents. For this reason, the development of a systematic NMR study of condensed benzimidazole compounds constitutes a significant tool in understanding the molecular dynamics and the structural parameters that govern their behavior. The H-1 and C-13 NMR spectra of new imidazobenzodiazepines were investigated. Based on the study of NMR chemical shifts, we discuss the environmental effect of the nucleus C-13. The correlation H-1-C-13 proved to be a useful method for distinguishing the assignment of carbon. (C) 2010 King Saud University. Production and hosting by Elsevier B. V. All rights reserved.
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收藏
页码：523 / 526
页数：4
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