Emerging Role of YAP and the Hippo Pathway in Prostate Cancer

被引：13

作者：

Koinis, Filippos ^{[1
,2
]}

Chantzara, Evangelia ^{[1
]}

Samarinas, Michael ^{[3
]}

Xagara, Anastasia ^{[2
]}

Kratiras, Zisis ^{[4
]}

Leontopoulou, Vasiliki ^{[1
]}

Kotsakis, Athanasios ^{[1
,2
]}

机构：

[1] Univ Gen Hosp Larissa, Dept Med Oncol, Larisa 41221, Greece

[2] Univ Thessaly, Sch Hlth Sci, Lab Oncol, Fac Med, Larisa 41500, Greece

[3] Gen Hosp Koutlibanio, Dept Urol, Larisa 41221, Greece

[4] Univ Athens, Urol Dept 3, Attikon Univ Gen Hosp, Chaidari 12462, Greece

来源：

BIOMEDICINES | 2022年 / 10卷 / 11期

关键词：

prostate cancer; YAP/TAZ signaling; Hippo pathway; prostate cancer hallmarks; YAP; YES-ASSOCIATED PROTEIN; ORGAN SIZE CONTROL; CELL-CYCLE EXIT; TUMOR-SUPPRESSOR; SIGNALING PATHWAY; NUCLEAR-LOCALIZATION; TISSUE HOMEOSTASIS; CANDIDATE ONCOGENE; POOR-PROGNOSIS; PHASE-II;

D O I：

10.3390/biomedicines10112834

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Hippo pathway regulates and contributes to several hallmarks of prostate cancer (PCa). Although the elucidation of YAP function in PCa is in its infancy, emerging studies have shed light on the role of aberrant Hippo pathway signaling in PCa development and progression. YAP overexpression and nuclear localization has been linked to poor prognosis and resistance to treatment, highlighting a therapeutic potential that may suggest innovative strategies to treat cancer. This review aimed to summarize available data on the biological function of the dysregulated Hippo pathway in PCa and identify knowledge gaps that need to be addressed for optimizing the development of YAP-targeted treatment strategies in patients likely to benefit.

引用

页数：18

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