Functional aspects on the pathophysiology of portal hypertension in cirrhosis

被引：228
作者：
Garcia-Pagan, Juan-Carlos [1 ]
Gracia-Sancho, Jorge [1 ]
Bosch, Jaume [1 ]
机构：
[1] Hosp Clin Barcelona, Liver Unit, Hepat Hemodynam Lab, IMDIM,IDIBAPS, E-08036 Barcelona, Spain
来源：
JOURNAL OF HEPATOLOGY | 2012年 / 57卷 / 02期
关键词：
Intrahepatic vascular resistance; Nitric oxide; Thromboxane A(2); Antioxidants; Angiogenesis; NITRIC-OXIDE; RAT LIVERS; ENDOTHELIAL DYSFUNCTION; CELL ACTIVATION; PRESSURE; CIRCULATION; INHIBITION;
D O I：
10.1016/j.jhep.2012.03.007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：458 / 461
页数：4
相关论文
共 13 条
[1]   Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial [J].
Abraldes, Juan G. ;
Albillos, Agustin ;
Banares, Rafael ;
Turnes, Juan ;
Gonzalez, Rosario ;
Garcia-Pagan, Juan Carlos ;
Bosch, Jaime .
GASTROENTEROLOGY, 2009, 136 (05) :1651-1658
[2]   Hepatic endothelial dysfunction and abnormal angiogenesis: New targets in the treatment of portal hypertension [J].
Bosch, Jaume ;
Abraldes, Juan G. ;
Fernandez, Mercedes ;
Carlos Garcia-Pagan, Juan .
JOURNAL OF HEPATOLOGY, 2010, 53 (03) :558-567
[3]   Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence [J].
DeLeve, Laurie D. ;
Wang, Xiangdong ;
Guo, Yumei .
HEPATOLOGY, 2008, 48 (03) :920-930
[4]   Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats [J].
Fernandez, M ;
Mejias, M ;
Angermayr, B ;
Garcia-Pagan, JC ;
Rodés, J ;
Bosch, J .
JOURNAL OF HEPATOLOGY, 2005, 43 (01) :98-103
[5]   Increased oxidative stress in cirrhotic rat livers:: A potential mechanism contributing to reduced nitric oxide bioavailability [J].
Gracia-Sancho, Jorge ;
Lavina, Barbara ;
Rodriguez-Vilarrupla, Aina ;
Garcia-Caldero, Hector ;
Fernandez, Mercedes ;
Bosch, Jaume ;
Garcia-Pagan, Joan-Carles .
HEPATOLOGY, 2008, 47 (04) :1248-1256
[6]   Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers [J].
Gracia-Sancho, Jorge ;
Lavina, Barbara ;
Rodriguez-Vilarrupla, Aina ;
Garcia-Caldero, Hctor ;
Bosch, Jaime ;
Garcia-Pagan, Joan Carles .
JOURNAL OF HEPATOLOGY, 2007, 47 (02) :220-227
[7]   Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers [J].
Graupera, M ;
García-Pagán, JC ;
Parés, M ;
Abraldes, JG ;
Roselló, J ;
Bosch, J ;
Rodés, J .
JOURNAL OF HEPATOLOGY, 2003, 39 (04) :515-521
[8]   Mechanisms of extrahepatic vasodilation in portal hypertension [J].
Hennenberg, M. ;
Trebicka, J. ;
Sauerbruch, T. ;
Heller, J. .
GUT, 2008, 57 (09) :1300-1314
[9]   The hyperdynamic circulation of chronic liver diseases: From the patient to the molecule [J].
Iwakiri, Y ;
Groszmann, RJ .
HEPATOLOGY, 2006, 43 (02) :S121-S131
[10]   Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A2 [J].
Steib, Christian J. ;
Gerbes, Alexander L. ;
Bystron, Markus ;
den Winkel, Mark op ;
Haertl, Josef ;
Roggel, Frigga ;
Pruefer, Thomas ;
Goeke, Burkhard ;
Bilzer, Manfred .
JOURNAL OF HEPATOLOGY, 2007, 47 (02) :228-238
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