HER2 status in unusual histological variants of gastric adenocarcinomas

被引：38
作者：
Giuffre, Giuseppe [1 ]
Ieni, Antonio [1 ]
Barresi, Valeria [1 ]
Caruso, Rosario Alberto [1 ]
Tuccari, Giovanni [1 ]
机构：
[1] Univ Messina, AOU Polyclin G Martino, Dept Human Pathol, Sect Pathol Anat, I-98125 Messina, Italy
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2012年 / 65卷 / 03期
关键词：
TOPOISOMERASE-II-ALPHA; IN-SITU HYBRIDIZATION; GENE AMPLIFICATION; HEPATOID ADENOCARCINOMA; CELL CARCINOMA; PROTEIN EXPRESSION; HER-2/NEU ONCOGENE; PROGNOSTIC-FACTOR; CANCER; OVEREXPRESSION;
D O I：
10.1136/jclinpath-2011-200345
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aim To investigate HER2 status in a cohort of 109 gastric adenocarcinomas also including unusual variants, such as 14 hepatoid (HAS) and 9 mitochondrion-rich (MRC), characterised by an opposing clinical behaviour. Methods and Results Using HercepTest (DAKO) and FISH test (pharmDx DAKO), HER2 overexpression/amplification was encountered in 23 of 109 (21.10%) of all gastric adenocarcinomas. A progressive increase in HER2 overexpression was observed moving from the poorly cohesive histotype to MRC, tubular adenocarcinomas and HAS. A statistically significant difference was found between poorly cohesive carcinomas and the others; a similar significant difference was encountered between HAS and all other variants of adenocarcinoma. HER2 overexpression was significantly associated with high grade, advanced stage, high Ki-67 labelling index value and death from gastric cancer. Multivariate analysis identified HER2 overexpression as an independent unfavourable prognostic variable for adenocarcinomas as a whole and also for the HAS variant. Conclusions Trastuzumab has been confirmed as an additional useful therapeutic standard option for patients with HER2-positive advanced gastric cancers, and also in aggressive variants of adenocarcinomas such as HAS.
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收藏
页码：237 / 241
页数：5
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