Treatment of Older Patients with High-Risk Myelodysplastic Syndromes (MDS): The Emerging Role of Allogeneic Hematopoietic Stem Cell Transplantation (Allo HSCT)

被引：12

作者：

Atallah, Ehab ^{[1
]}

Bylow, Kathryn ^{[1
]}

Troy, Jesse ^{[2
]}

Saber, Wael ^{[1
,3
]}

机构：

[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[2] EMMES Corp, Rockville, MD 20850 USA

[3] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

来源：

CURRENT HEMATOLOGIC MALIGNANCY REPORTS | 2014年 / 9卷 / 01期

关键词：

MDS; Allogeneic hematopoietic stem cell transplantation; Age; Comprehensive geriatric assessment; Hypomethylating agents; ACUTE MYELOID-LEUKEMIA; COMPREHENSIVE GERIATRIC ASSESSMENT; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; PROGNOSTIC SCORING SYSTEM; UNITED-STATES; BIOLOGICAL ASSIGNMENT; CHEMOTHERAPY TOXICITY; ELDERLY-PATIENTS; PHASE-III;

D O I：

10.1007/s11899-013-0195-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MDS are myeloid clonal hematologic disorders that are most commonly diagnosed in the seventh decade of life. Several treatment options are currently available. However, allo HSCT remains the only curative therapy. Unfortunately, despite the higher incidence of MDS in the older population, less than 10 % of patients undergoing allo HSCT for MDS are > 65 years old. In this paper we discuss the various treatment options in older patients with high-risk MDS with particular emphasis on the role of allo HSCT in older MDS patients.

引用

页码：57 / 65

页数：9

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