Association of bone turnover markers with mortality in women referred to coronary angiography: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

被引：20

作者：

Lerchbaum, E. ^{[1
]}

Schwetz, V. ^{[1
]}

Pilz, S. ^{[1
,2
,3
]}

Boehm, B. O. ^{[4
]}

Maerz, W. ^{[5
,6
,7
,8
]}

机构：

[1] Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, A-8036 Graz, Austria

[2] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[4] Univ Ulm, Dept Internal Med, Div Endocrinol & Diabet, D-89069 Ulm, Germany

[5] Heidelberg Univ, Mannheim Med Fac, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim, Germany

[6] Med Univ Graz, Inst Clin Med, A-8036 Graz, Austria

[7] Med Univ Graz, Chem Lab Diagnost, A-8036 Graz, Austria

[8] SynlabAcad, Mannheim, Germany

来源：

OSTEOPOROSIS INTERNATIONAL | 2014年 / 25卷 / 02期

关键词：

Beta-crosslaps; Bone turnover; Cardiovascular disease; Mortality; Osteocalcin; LOW FREE TESTOSTERONE; VITAMIN-D; MINERAL DENSITY; OLDER MEN; INSULIN-RESISTANCE; HEART-FAILURE; ALL-CAUSE; OSTEOCALCIN; DISEASE; DEFICIENCY;

D O I：

10.1007/s00198-013-2411-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the association of fatal events with beta-crosslaps (beta-CTX) and osteocalcin (OC) concentrations in women. We observed an independent association of beta-CTX and OC concentrations with fatal events in women at high to intermediate cardiovascular risk. There is some evidence suggesting an association of beta-CTX and OC with fatal events in men and frail elderly subjects. We aimed to examine the association of fatal events with beta-CTX and OC in women. We measured beta-CTX and OC in 986 women aged 65 (58-72) years referred to coronary angiography. Compared to the first beta-CTX quartile, the crude hazard ratios (HRs) for all-cause and cardiovascular mortality in the highest beta-CTX quartile were 2.50 (1.65-3.81) and 3.28 (1.82-5.91), respectively. In multivariate adjusted models, HRs for all-cause and cardiovascular mortality in the highest beta-CTX quartile were 1.72 (1.09-2.70) and 2.31 (1.24-4.32), respectively. The lowest 25-hydroxyvitamin D [25(OH)D] quartile was significantly associated with increased risk of all-cause and cardiovascular mortality in multivariate adjusted models. In those models, the highest beta-CTX quartile was associated with an increased risk of all-cause and cardiovascular mortality. For OC concentrations, we found a reverse J-shaped association with noncardiovascular mortality. Using the first quartile as reference, crude and multivariate adjusted HRs for noncardiovascular mortality in the second and third OC quartile were 0.41 (0.19-0.90) [multivariate: 0.40 (0.18-0.88)] and 0.51 (0.25-1.06) [multivariate: 0.43 (0.20-0.94)], respectively. The lowest 25(OH)D quartile was associated with a trend towards increased risk of noncardiovascular mortality in multivariate analysis. In that analysis, OC quartile 2 and 3 were significantly associated with lower risk of noncardiovascular mortality. We observed an independent association of high beta-CTX with all-cause and cardiovascular mortality and a reverse J-shaped association of OC with noncardiovascular mortality.

引用

页码：455 / 465

页数：11