Leptomeningeal Carcinomatosis Molecular Landscape, Current Management, and Emerging Therapies

被引:19
作者
Bhambhvani, Hriday P. [1 ]
Rodrigues, Adrian J. [1 ]
Umeh-Garcia, Maxine C. [1 ]
Gephart, Melanie Hayden [1 ,2 ]
机构
[1] Stanford Univ, Med Ctr, Dept Neurosurg, 300 Pasteur Dr, Palo Alto, CA 94305 USA
[2] Stanford Univ, Sch Med, Brain Tumor Ctr, Dept Neurosurg, 300 Pasteur Dr, Palo Alto, CA 94305 USA
关键词
Cellular; Disease; Metastasis; Cell; Pathophysiology; Translational; Brain; CENTRAL-NERVOUS-SYSTEM; CELL LUNG-CANCER; DOSE INTRAVENOUS METHOTREXATE; WHOLE-BRAIN RADIOTHERAPY; GROWTH-FACTOR VEGF; BREAST-CANCER; CEREBROSPINAL-FLUID; NEOPLASTIC MENINGITIS; SOLID TUMORS; INTRAVENTRICULAR CHEMOTHERAPY;
D O I
10.1016/j.nec.2020.06.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Leptomeningeal carcinomatosis is a devastating consequence of late-stage cancer, and despite multimodal treatment, remains rapidly fatal. Definitive diagnosis requires identification of malignant cells in the cerebrospinal fluid (CSF), or frank disease on MRI. Therapy is generally palliative and consists primarily of radiotherapy and/or chemotherapy, which is administered intrathecally or systemically. Immunotherapies and novel experimental therapies have emerged as promising options for decreasing patient morbidity and mortality. In this review, the authors discuss a refined view of the molecular pathophysiology of leptomeningeal carcinomatosis, current approaches to disease management, and emerging therapies. © 2020 Elsevier Inc.
引用
收藏
页码:613 / 625
页数:13
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