Direct C-2 Acylation of Thiazoles with Aldehydes via Metal-and Solvent-Free C-H Activation in the Presence of tert-Butyl Hydroperoxide

被引：14

作者：

Khemnar, Ashok B. ^{[1
]}

Bhanage, Bhalchandra M. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Chem, Bombay 400019, Maharashtra, India

来源：

SYNLETT | 2014年 / 25卷 / 01期

关键词：

acylation; C-H activation; oxidative cross-coupling; metal-free; solvent-free; CATALYZED ORTHO-ACYLATION; ALPHA-OXOCARBOXYLIC ACIDS; ONE-POT SYNTHESIS; BOND ACYLATION; DECARBOXYLATIVE ACYLATION; OXIDATIVE CYCLIZATION; DIRECT ALKYNYLATION; DIRECT ALKYLATION; DIRECT ARYLATION; AZOLES;

D O I：

10.1055/s-0033-1340068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient methodology for the synthesis of heteroaryl ketones by C-H activation of aldehydes and thiazoles is developed. The reaction occurs smoothly, under metal-, acid- and solvent-free conditions using tert-butyl hydroperoxide as the oxidant under an air atmosphere, to afford a wide range of heteroaryl ketones in moderate to good yields. The sp(2) C-H bonds in the aldehyde and thiazole undergo direct oxidative cross-coupling, resulting in C-2 acylation of the azole.

引用

页码：110 / 114

页数：5

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