Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy

被引：26

作者：

Silva, Erika F. ^{[1
]}

Charreau, Isabelle ^{[6
]}

Gourmel, Bernard ^{[2
]}

Mourah, Samia ^{[3
]}

Kalidi, Issa ^{[4
]}

Guillon, Brigitte ^{[6
]}

De Castro, Nathalie ^{[1
]}

Caron, Francois ^{[7
]}

Braun, Josephine ^{[6
]}

Molina, Jean-Michel ^{[1
,5
]}

机构：

[1] Univ Paris 07, Hop St Louis, AP HP, Dept Infect Dis,Paris Sorbonne Cite, Paris, France

[2] Univ Paris 07, Hop St Louis, AP HP, Biochem Lab,Paris Sorbonne Cite, Paris, France

[3] Univ Paris 07, Hop St Louis, AP HP, Pharmacol Lab,Paris Sorbonne Cite, Paris, France

[4] Univ Paris 07, Hop St Louis, AP HP, Hemostasis Lab,Paris Sorbonne Cite, Paris, France

[5] INSERM, U941, Paris, France

[6] INSERM, SC10, Villejuif, France

[7] CHU Hop Rouen, Dept Infect Dis, Rouen, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 06期

关键词：

HIV; enfuvirtide; raltegravir; IL-6; CRP; D-dimer; switch; biomarkers; MARKERS; TENOFOVIR/EMTRICITABINE; EFAVIRENZ; WOMEN;

D O I：

10.1093/infdis/jit280

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stored plasma specimens from 164 participants in the ANRS 138 trial were analyzed to determine interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels at baseline and weeks 24 and 48. These virologically suppressed, treatment-experienced patients were randomly assigned to undergo an immediate switch (IS) or a deferred switch (DS; at week 24) from an enfuvirtide-based antiretroviral therapy (ART) regimen to a raltegravir-based regimen. At week 24, a significant decrease from baseline was observed in the IS arm, compared with the DS arm, for IL-6 level (-30% vs +10%; P < .002), hsCRP level (-46% vs +15%; P < .0001), and D-dimer level (-40% vs +6%; P < .0001). At week 48, there was a reproducible decrease in levels of all biomarkers in the DS arm.

引用

页码：892 / 897

页数：6

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