Calcium crystal deposition diseases: Update on pathogenesis and manifestations

被引：27
作者：
Molloy, ES
McCarthy, GM
机构：
[1] Cleveland Clin Fdn, Dept Rheumat & Immunol Dis, Cleveland, OH 44195 USA
[2] Royal Coll Surgeons Ireland, Dept Mol & Cellular Therapeut, Dublin 2, Ireland
[3] Mater Misericordiae Univ Hosp, Dept Rheumatol, Dublin 7, Ireland
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2006年 / 32卷 / 02期
关键词：
D O I：
10.1016/j.rdc.2006.02.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate crystals are the most common types of pathologic calcium-containing crystals. Although these crystals long have been associated with a variety of rheumatic syndromes, recent evidence implicates BCP crystals in the pathogenesis of breast cancer and atherosclerosis. Although understanding of molecular mechanisms involved in generating these pathologic effects has been advanced significantly in recent years, they still are understood incompletely. Such advances are essential to the ongoing search for effective therapies for crystal-associated diseases.
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页码：383 / +
页数：19
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