Ruthenium-Catalyzed Transfer Hydrogenation of Amino- and Amido-Substituted Acetophenones

被引：16

作者：

Watson, Andrew J. A. ^{[1
]}

Fairbanks, Antony J. ^{[1
]}

机构：

[1] Univ Canterbury, Dept Chem, Christchurch 8041, New Zealand

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 30期

关键词：

Ruthenium; Homogeneous catalysis; Hydrogen transfer; Reduction; ASYMMETRIC TRANSFER-HYDROGENATION; ENANTIOSELECTIVE REDUCTION; BORROWING HYDROGEN; KETONES; EFFICIENT; LIGANDS; COMPLEXES; ALCOHOLS; ALDEHYDES; DIAMINE;

D O I：

10.1002/ejoc.201301020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ruthenium-catalyzed transfer hydrogenation of electron-rich amino-substituted acetophenones is reported. Variation of the reductant, ligands, base, and solvent allowed reaction optimization. A key discovery was the use of 1,4-butanediol as an irreversible reducing agent, which significantly improved the conversion. A range of amino- and amido-substituted aryl ketones were explored, and they all gave the corresponding alcohols in good yield, which demonstrates the wider applicability of this process.

引用

页码：6784 / 6788

页数：5

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