Gene duplication and biased functional retention of paralogs in bacterial genomes

被引：136

作者：

Gevers, D ^{[1
]}

Vandepoele, K ^{[1
]}

Simillion, C ^{[1
]}

Van de Peer, Y ^{[1
]}

机构：

[1] State Univ Ghent VIB, B-9052 Ghent, Belgium

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 04期

关键词：

D O I：

10.1016/j.tim.2004.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene duplication is considered an important prerequisite for gene innovation that can facilitate adaptation to changing environments. The analysis of 106 bacterial genome sequences has revealed the existence of a significant number of paralogs. Analysis of the functional classification of these paralogs reveals a preferential enrichment in functional classes that are involved in transcription, metabolism and defense mechanisms. From the organization of paralogs in the genome we can conclude that duplicated genes in bacteria appear to have been mainly created by small-scale duplication events, such as tandem and operon duplications.

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页码：148 / 154

页数：7

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